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Hormone Injections may help the Obese

Oxyntomodulin injections may reduce weight in obese patients Research by Steve Bloom

Weight loss injections

It may be possible to “feel full” without actually “filling up”.  Researchers gave obese patients injections of the natural hormone Oxyntomodulin.  The hormone is normally found in the small intestines.  The hormone acts as a signal telling the brain the body has had enough to eat.  The injections boosted the levels of Oxyntomodulin in the body. 

The lead researcher Professor Steve Bloom at the Imperial College in London an Hammersmith Hospital told Best Syndication that Oxyntomodulin "cannot be taken orally.  A nasal spray sounds reasonable but has never been tested".  He compared 14 subjects given oxyntomodulin injections with 12 given plain saline injections.  After 4 weeks they found that the oxyntomodulin group lost an average 2.3 kg compared to .3kg lost by the control group. 

The groups self-administered the injections 3 times a day thirty minutes before each meal.  The injections caused a reduced caloric intake after the first injection of 170 calories.  By the end of the trial the subjects reduced their calories by 250 per meal.    

 

Earlier research found that Oxyntomodulin levels went up in patients that had gastric bypass surgery.  Many speculated that increasing the levels of the hormone would lead to weight reduction.  It appears they were right.

There are other hormones that can produce the ‘full” feeling.  Dr. Bloom reported three years ago that PYY3-36 produced a significant reduction in weight in rats by reducing their appetite.  The short term trials of a nasal spray produced weight loss of 5 pounds a month, or about the same as Oxyntomodulin.  Dr. Bloom told Best Syndication  "PYY maybe works by inhibiting and appetite circuit (NPY) in the hypothalamus  so has a lower max effect but lasts hours.  Oxyntomodulin maybe inhibits directly and is short acting so a depot or other long acting preparation would be optimal.  They have never been tested head to head and the only 4 week human study is for Oxyntomoduin."

There are other anti-obesity drugs on the market.  Oxyntomodulin has the benefit because they have no observed side effects.  For instance, the drug Meridia can raise blood pressure and increase heart rate.  Bloom told Best Syndication that neither treatment is costly to manufacturer (PYY3-36 or Oxyntomodulin).

Steve hopes the study will lead to a solution to obesity in our society. He is also looking into a method of administering the hormone without having to diet jab or inject it. The research was published in the journal Diabetes


By Dan Wilson
Best Syndication Staff Writer

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Copyright 2005 Best Syndication                                            Last Updated Saturday, July 10, 2010 09:40 PM