Hormone Injections may
help the Obese
It may be possible to “feel full” without actually
“filling up”. Researchers gave obese patients injections of the natural
hormone Oxyntomodulin. The hormone is normally found in the small
intestines. The hormone acts as a signal telling the brain the body has
had enough to eat. The injections boosted the levels of Oxyntomodulin
in the body.
The lead researcher Professor Steve Bloom at the
Imperial College in London an Hammersmith Hospital told Best
Syndication that Oxyntomodulin "cannot be taken orally. A
nasal spray sounds reasonable but has never been tested". He compared 14
subjects given oxyntomodulin injections with 12 given plain saline
injections. After 4 weeks they found that the oxyntomodulin group lost
an average 2.3 kg compared to .3kg lost by the control group.
The groups self-administered the injections 3 times a
day thirty minutes before each meal. The injections caused a reduced
caloric intake after the first injection of 170 calories. By the end of
the trial the subjects reduced their calories by 250 per meal.
Earlier research found that Oxyntomodulin levels went
up in patients that had
gastric bypass surgery. Many speculated that
increasing the levels of the hormone would lead to weight reduction. It
appears they were right.
There are other hormones that can produce the ‘full”
feeling. Dr. Bloom reported three years ago that
PYY3-36 produced a
significant reduction in weight in rats by reducing their appetite. The
short term trials of a nasal spray produced weight loss of 5 pounds a
month, or about the same as Oxyntomodulin. Dr. Bloom told Best
Syndication "PYY maybe
works by inhibiting and appetite circuit (NPY) in the hypothalamus so
has a lower max effect but lasts hours. Oxyntomodulin maybe
inhibits directly and is short acting so a depot or other long acting
preparation would be optimal. They have never been tested head to
head and the only 4 week human study is for Oxyntomoduin."
There are other anti-obesity drugs on the market.
Oxyntomodulin has the benefit because they have no observed side
effects. For instance, the drug
Meridia can raise blood pressure and
increase heart rate. Bloom told Best Syndication that
neither treatment is costly to manufacturer (PYY3-36 or Oxyntomodulin).
Steve hopes the study will lead to a solution to
obesity in our society. He is also looking into a method of
administering the hormone without having to
diet jab or inject it. The
research was published in the journal
Best Syndication Staff Writer
Keywords and misspellings: Diet dieting deit