Pargluva Drug for
Diabetes found to be Dangerous
October 22nd 2005
Cost of Diabetes
A new treatment for
type-2 diabetes may double the risk of death according to researchers at
the Cleveland Clinic. If the analysis is correct Pargluva (muraglitazar
is the generic name), a drug developed by Bristol-Myers Squibb and Merck
& Company, could cause a “public health catastrophe”.
The research was
published by the
Journal of the American Medical Association. Muraglitazar is a new
drug used to treat both high glucose levels and improve blood lipids.
The drug was approved on October 18th by the Food and Drug
The Journal reports
that “in a review of data from Phase 2 and 3
trials conducted by the drug manufacturer and provided to the FDA,
Nissen and colleagues found that muraglitazar was associated with an
excess incidence of the composite endpoint of death, major adverse
cardiovascular events, and congestive heart failure.”
new findings could prevent a disaster since 18 million Americans suffer
from diabetes. Dr. Steven Nissen told reporters that “this is a Vioxx
that isn’t going to happen”. The FDA has not made a comment about the
new findings yet.
Bristol-Myers Squibb and Merck said in a statement that Pargluva "was
extensively studied, and all available data were reported to the FDA."
It was hoped that Pargluva would be the first diabetes drug designed to
lower blood sugar, reduce fatty triglycerides and increase levels of
"good" cholesterol, according to Nissen.
According to an editorial author Dr. James Brophy at the McGill
University “Company-provided data might have fostered an "illusion of
safety" because of numerous omissions, such as excluding patients most
likely to face cardiovascular risks, including elderly diabetics” the
Indianapolis Star reported
Dr. Nissen also said "I expected the advisory panel to turn the drug
down." Of the 18 million diabetics roughly 80% will die from the
disease. If the drug is used it should be scrutinized and high risk
patients should not take it.
By Dan Wilson
Best Syndication Staff Writer
Books on Diabetes
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