Blocking the IKK2
Protein may Prevent Brain Damage Due to Stroke
November 15th 2005
Mouse study gives
German and Italian
scientists believe they have found a protein trigger for cell death,
which leads to stroke damage. This important discovery was reported in
the journal Nature Medicine.
The researchers at
the Universities of Heidelberg and Ulm and a unit of
the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy,
identified a signal in brain cells that tell them to die after a
stroke. They believe they can control the protein trigger and save
victims from cell death.
Cell death occurs
when blood flow is interrupted to the brain or a portion of the brain. It
may be possible to prevent the cell death if the switched is blocked.
Preventing the cell death could reduce the effects of the stroke
including paralysis and speech impairment.
created a stroke-like condition in mice. They focused on an internal
cell communications network called NF-kB. This network comes into play
when brain cells are damaged, triggering cells to self destruct. They
found that the protein IKK2 activated NF-kB.
The mice with
an over-active form of IKK2 in the neurons had far more brain cells die.
Blocking the IKK2 signal blocked the cell death. The mice where
cells stayed alive appeared to show signs of recovery. The Damaged cell
tissue was still alive several days after the stroke.
include a regimen of clot-busting drugs. It is hoped that a treatment
involving IKK2 protein blockers is developed. This could save millions of lives a
year and help prevent dehabilitating strokes. Stroke is the third most
common form of death in the US behind heart disease and cancer. New
article concerning stroke treatment.
By Dan Wilson
Best Syndication Staff Writer
Keywords and misspellings: stroak strok prevention
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