Mayo Clinic Research
determines A Cause for Cancer Cell Mutations
December 16th
2005
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Cell Structure |
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New research published in the December 15th issue journal Nature may
explain why some cells are naturally “cancer proofed”. A mechanism or
state called aneuploidy (AN-u-ploy-dee) may have something to do with
it. Aneuploidy is a state where a cell has an abnormal number of
chromosomes that creates cellular instability, giving rise to tumors.
The research was led by Dr. Jan van Deursen PhD at the Mayo Clinic. Van
Deursen told Best Syndication that "What we discovered is that there's
an active process of cellular machinery that prevents aneuploidy. It's
a surveillance mechanism involving the two proteins Rae1-Nup98 that
makes sure that in every cell division the proper number of chromosomes
occur.”
There are two key proteins that work to cancer-proof a cell. These
proteins prevent premature segregation of duplicate chromosomes during
cell (nuclear) division. The new cancer players comprise a two-protein
complex Rae1-Nup98.
The proteins act as a cell division auditing system to ensure the right
number of chromosomes is distributed to each newly formed cell. When
the wrong number of chromosomes is distributed between cells during
division, mutations and cancer can occur. These protein help promote
“eupolidy” which is the ideal chromosome distribution.
Dr. van Deursen hopes this research leads to a more effective treatment
of cancer that is “gentler than the current radiation and chemotherapy
treatments used”. Until now the standard knowledge was that the
aneuploidy mechanism was controlled by a single cellular system. Since
95% of all cancers involve aneuploidy this discovery may help doctors
cancer-proof cells.
By Dan Wilson
Best Syndication Staff Writer
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