HGH and Growth Disorders – New Understandings of Human Growth Hormone gene and RNA controls of Genomic Expression

HGH and Growth Disorders – New Understandings of Human Growth Hormone gene and RNA controls of Genomic Expression

Researchers from the University of Pennsylvania School of Medicine discovered a unique mechanism that had extensive genomic distance and controls of human growth hormone (hGH). The researchers discovered a set of “non-coding RNAs” that was expressed near the location of the hGH gene in the pituitary gland.

The researchers analyzed 14,000 base pairs which separated the hGH gene along with its locus control region. They discovered that the locus control region was copied into the RNA. The gene called CD79b was within this region. CD79b gene is normally found to code for a protein in blood lymphocytes. In this case the researchers found it did a completely different function in the pituitary gland. The researchers confirmed that the CD79b non-coding DNA does have a significant role in hGH gene expression.

The researchers hope to further understand how the non-coding RNAs and the hGH gene work together. By understanding how the hGH gene is expressed their may be new therapeutic treatments for genetic disorders of growth hormone defects.

"Our data predict that a subset of children with short stature and low growth hormone may be suffering from a mutation in the hGH locus control region, which blocks full levels of hGH gene activity," said co-author Yugong Ho, PhD, an Instructor of Genetics at Penn. "We are now actively screening the appropriate clinical populations for such genetic defects."

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