Insulin Resistance increase with excessive Upper Body Fat on Chest and Back

Insulin Resistance increase with excessive Upper Body Fat on Chest and Back

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[Best Syndication] Researchers from the San Francisco VA Medical Center found an increased risk of insulin resistance when a person had extra fat located on their chest and back. Insulin resistance is a early symptom that develops before type 2 diabetes is diagnosed.

The researchers looked at HIV infected participants and those without HIV which were used as a control subject in a Study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM), which is a long-term study of HIV patients that are taking antiretroviral therapy.

The researchers found that extra fat in between and surrounding internal organs was also another type of fat that increased the risk of insulin resistance in both groups. Both the extra fat on the chest and back and the visceral fat in the organs contributed to insulin resistance. They both were contributing to the increase of insulin resistance even when the other type of fat wasn’t present.

“We knew about the insulin resistance risk associated with visceral fat, which has been shown in previous studies, but no one had ever looked at the contribution of upper trunk fat,” says lead author and FRAM principal investigator Carl Grunfeld, MD, PhD, chief of the metabolism and endocrine sections at SFVAMC. “Strikingly, there was very little difference between HIV infected people and controls. If you have fat up top, it’s bad for you.”

Grunfeld explains the lack of difference in risk between HIV infected and HIV negative subjects by noting that two thirds of all Americans are overweight and one third are obese. “With the new, highly effective antiretroviral medications, Americans with HIV now have the same weight problems as everybody else,” he says. “No matter who you are, if you eat too much and you don’t exercise, you’re going to be at risk for insulin resistance, cardiovascular disease, and every other problem associated with being overweight.”

By Mark Barone
Best Syndication News Health Writer



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