Birth Defects linked with Long-Term High-Dose intake of Diflucan (Fluconazole) during First Trimester of Pregnancy

Medicine bottle - BSN

(Best Syndication News) - The US Food and Drug Administration (FDA) announced a public warning that taking high doses of Diflucan (fluconazole) during the first trimester of pregnancy could increase the risk for the baby to develop an uncommon and discrete set of birth defects. Only long-term doses between 400-800 mg per day are associated with the birth defect risk. A one-time use of 150 mg dose did not have the birth defect risk.

Fluconazole is commonly used to treat vaginal yeast infections called candidiasis. It can also be used to treat yeast infections in other parts of the body. The medication can also be used to treat meningitis for a specific kind of fungus.

The FDA has changed the higher dose fluconazole from a category C to category D because of the pregnancy risk.

The FDA said that in certain serious or life-threatening circumstances, fluconazole could be used with pregnant women.

If a women is taking high doses of fluconazole, healthcare professionals should educate the patient of the risks for birth defects if they should become pregnant, says the FDA. Additionally, if the patient does become pregnant while taking the medication, they should notify their doctor.

By: Marsha Quinn

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