Topical Simvastatin accelerated wound healing in diabetic mice

Foot - BSN

(Best Syndication News) - A study involving diabetic mice found that applying simvastatin topically to the wound sped-up healing. The research suggests that the topical simvastatin could offer a similar benefit for humans dealing with problems like a diabetic foot ulcer and other wounds that are slow to heal. The researchers published their findings in The American Journal of Pathology.

The study was conducted at the Departments of Dermatology and Ophthalmology of Kyoto Prefectural University School of Medicine, Kyoto, Japan; the Department of Dermatology at Hamamatsu University School of Medicine, Hamamatsu, Japan; and the Shiseido Innovative Scientific Research Center, Yamamoto, Japan.

Lead investigator, Jun Asai, MD, PhD., said that several factors delay wound healing in diabetics. Fast cell death and a reduction in the growth of new blood vessels can slow the healing process. Additionally, a diabetic person has impairment in the creation of new lymphatic vessels.

Other studies have suggested that statins have additional benefits besides their common use for reducing blood cholesterol levels. Statins are believed to encourage the growth of new blood vessels when taken as a pill. The researchers wanted to see if applying simvastatin to the wound would help grow new blood vessels and make new lymphatic vessels. The researchers point out that there is a benefit to applying the medicine to the skin instead of taking a pill; topical applications would reduce the risk of kidney damage.

To test the simvastatin ointment, the researchers created full-thickness skin wounds on the backs of diabetic mice. They mixed simvastatin with petroleum jelly, and for the control, they used only petroleum jelly. The wound was treated with the ointment on the first day, the fourth day, the seventh day, and the tenth day.

In just two weeks 90 percent of the mice treated with simvastatin ointment had their wounds heal; less than 80 percent of the control group was healed. The difference in the wound closure was most obvious on day seven, with 79.26 percent of the simvastatin group healed compared to only 52.45 percent in the control group.

More research would be needed to determine if a topical simivastin ointment for the skin would help wound healing in humans with diabetes.

By: Marsha Quinn
Health Reporter

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