Atrial Fibrillation combined with Chronic Kidney Disease increase risk for ESRD

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(Best Syndication New) - Researchers from the University of California, San Francisco (UCSF) and the Kaiser Permanente Northern California Division of Research, found an increased risk for kidney failure in people who have atrial fibrillation and chronic kidney disease. In general, kidney function can fail over time with the chronic condition which can lead to dialysis treatments or a kidney transplant. Kidney problems are more likely to worsen in atrial fibrillation patients who already have kidney function impairment. The study results were published in the journal Circulation.

Irregular heart rhythm is a very common type of atrial fibrillation. Patients who have atrial fibrillation along with chronic kidney disease or end stage-renal disease (ESRD) are at an increased risk for suffering from a stroke or death. The researchers wanted to understand why atrial fibrillation patients with kidney disease are more likely to have end-stage renal disease compared to those with chronic kidney disease only.

The study involved 206,229 adults who were diagnosed with chronic kidney disease from the Kaiser Permanente Northern California healthcare system. Within five years, around 16,400 of the chronic kidney patients also developed atrial fibrillation. The researchers discovered that those with atrial fibrillation and chronic kidney disease had a 67 percent increased risk for progression to end-stage renal disease compared to those that did not develop atrial fibrillation.

"This study addresses that gap and may have important implications for clinical management by providing better prognostic information and leading to future work determining how to improve outcomes in this high-risk group of patients," said senior author, Alan S. Go, MD, director of the Comprehensive Clinical Research Unit at the Kaiser Permanente Division of Research.

More research will be needed to determine why there is an increased risk for developing end-stage renal disease in these patients.

By: Marsha Quinn
Health Reporter

Ref: "Incident Atrial Fibrillation and Risk of End-Stage Renal Disease in Adults with Chronic Kidney Disease." Nisha Bansal, Dongjie Fan, Chi-yuan Hsu, Juan D. Ordonez, Gregory M. Marcus and Alan S. Go. Internet. Circulation. Published onDec. 28, 2012.,1



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