Genetics and Stem Cells

Juxtapid (lomitapide) gains FDA approval

Prescription bottle - BSN

(Best Syndication News) - The U.S. Food and Drug Administration (FDA) approved Juxtapid (lomitapide) to treat a rare homozygous familial hypercholesterolemia (HoFH) disorder. Juxtapid should lower the low-density lipoprotein (LDL) cholesterol levels, the total cholesterol, apolipoprotein B, and non-high-density lipoprotein (non-HDL) cholesterol. The drug should be prescribed in conjunction with a low fat diet and other lipid reduction treatments.

In the United States, around one in one million people have HoFH. People with the rare condition do not effectively remove “bad” LDL cholesterol from their body. This puts HoFH individuals at an increased risk for heart attacks and death, often before the age of 30.

Scientist identify More Genetic causes of Coronary Artery Disease

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(Best Syndication News) - A large group of international scientists, including scientists from Standford University School of Medicine, has identified 15 new genetic areas that are related to coronary artery disease. With these new findings, there are now 46 genetic links related to heart disease. The research findings will be published in the December 2 online edition of Nature Genetics.

Coronary atherosclerosis, another name for plaque build-up in the artery wall of the heart vessels, is a condition that can cause a person to suffer chest pain or a heart attack. According the U.S. Centers for Disease Control, heart disease ranks as the leading cause of death in the United States.

Hereditary High Blood Cholesterol not Identified and Treated Effectively

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(Best Syndication News) - A research study from the University of Copenhagen and Herleve Hospital found that more Danes than previously thought have hereditary high blood cholesterol, and the condition is not being treated optimally. The study results were published in The Journal of Clinical Endocrinology & Metabolism.

Dr Børge Nordestgaard, clinical professor at the Faculty of Health and Medical Sciences and senior physician at Herlev Hospital, said of the 69,000 Danes investigated, they found that 1 out of 137 people in Denmark had hereditary high blood cholesterol.

New Treatment for Brain Swelling

Peter Humphries

(Best Syndication News) European researchers say they have come up with a new treatment to save the life of people suffering from swelling of the brain. Their method can safely manipulate the blood vessels in the brain to allow for a periodic opening of the channels between the blood vessels and the brain cell lining.

The goal is to relieve acute pressure on the brain caused by stroke, brain injury, tumors, or other conditions that can cause swelling. Over the years, there has been little change in the treatment of this condition, according to Dr. Matthew Campbell, of the Ocular Genetics Unit at Trinity College Dublin.

Coffee and Short Exercise Program Alters DNA

genetic sequence image

(Best Syndication News) Scientists say that a small amount of exercise by people who are normally sedentary can change their DNA “immediately.” Caffeine could change the structure of the DNA of muscles in a similar way.

Juleen Zierath of Karolinska Institutet in Sweden says that our muscles are really “plastic.” Muscles adapt to what we do. While the underlying genetic code of the muscle isn’t changed, the molecular structure of the DNA is chemically and structurally altered, according to Zierath.

“If you don't use it, you lose it, and this is one of the mechanisms that allows that to happen," Zierath explained. The exercise appears to genetically reprogram the muscle tissue for strength.

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