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Genetics and Stem Cells

Genetic Breakthrough in Breast Cancer Research – BRCA1 Gene Mutation Prevents Repair Of PTEN Gene – Drug Trials In Progress

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Genetic Breakthrough in Breast Cancer Research – BRCA1 Gene Mutation Prevents Repair Of PTEN Gene – Drug Trials In Progress

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(Best Syndication) Researchers believe they know why the mutation in the BRCA1 gene leads to breast cancer in some people. A worldwide investigation has led to the conclusion that the mutation knocks out the powerful tumor suppressor gene known as PTEN.

For 10 years researchers have been trying to figure out how the BRCA1 gene was related to breast cancer. In 1997 Ramon Parsons, M.D., Ph.D., the Avon Foundation Professor of Medicine and Pathology at Columbia University College of Physicians and Surgeons led one of two teams that identified the PTEN, one of the most important tumor suppressor genes altered in breast cancer.

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Insulin may play role in Aging associated with Klotho Gene

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Insulin may play role in Aging associated with Klotho Gene

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[Best Syndication] New understandings have been discovered with Klotho hormone and how insulin levels help to increase the levels of this anti-aging gene which is believed to extend life span in rodents and humans. Insulin is a hormone that is usually thought of with diabetes. But the researchers found that insulin also increases significantly the amount of Klotho that is secreted. Researcher, Carmela Abraham, a professor of biochemistry and medicine at Boston University School of Medicine (BUSM) reported the relationship of insulin with Klotho in the current week’s issue of the Proceedings of the National Academy of Sciences.

The researchers discovered that insulin regulates the secretion of Klotho. They first observed that Klotho levels in the brain decrease with aging. That further lead them to discover Klotho which is a protein that is found on certain cell membranes and is also found in serum and cerebrospinal fluid. The researchers suggest that the release of Klotho from the cell membrane is probably caused by an enzyme that causes the Klotho to be free to enter into the serum and cerebrospinal fluid.

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Questions Raised About Skin Cell and Embryonic Stem Cell Research

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Questions Raised About Skin Cell and Embryonic Stem Cell Research

Mouse embryonic stem cells

(Best Syndication) Researchers have found that they can revert adult human skin cells into cells that are identical to human embryonic stem cells. It is hoped that this process will eliminate the controversy surrounding embryonic stem cell research, but will it?

According to embryonic stem cell research supporters, their research is crucial. According to scientists in Japan and Wisconsin, the research isn’t very far along. There are also dangers involved. According to the report, cells injected with viruses could bring tumors or cancer. The good news is that since the skin cells came from the patient they will not be rejected.

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Skin Cells Made Into Embryonic Identical Stem Cells – Pluripotent Induced Breakthrough From Wisconsin University of Medicine

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Skin Cells Made Into Embryonic Identical Stem Cells – Pluripotent Induced Breakthrough From Wisconsin University of Medicine

James Thomson

(Best Syndication) Researchers in Wisconsin say that they have been able to “reprogram” human skin cells to create cells which are indistinguishable from embryonic stem cells. The good news is that the cells may be easily made with little expense, plus there are no ethical or legal constraints.

The authors warn that more research needs to be done to ensure that the "cells do not differ from embryonic stem cells in a clinically significant or unexpected way, so it is hardly time to discontinue embryonic stem cell research." The big advantage is that since the cells are from the patient’s own body, rejection drugs may not be needed with this new type of stem cell.

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Monkey Cloning from Oregon Researchers hope for Stem Cell research for Humans in the future

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Monkey Cloning from Oregon Researchers hope for Stem Cell research for Humans in the future

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[Best Syndication] Monkey embryo stem cells are being reported as being successful with cloning according to Oregon researchers. They have successfully duplicated monkey embryos from groups of stems cells.

The good part of cloning in the future could be the potential of growing replacement tissues and organs from your own cells which would leave no problems with rejection from the transplant. The research is being conducted currently with monkeys at the Oregon National Primate Research Center in Beaverton.

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