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Heart Patients taking Crestor Statin Prescription Drug removed Plaque Build-up in their Arteries

March 13th, 2006

Heart Patients taking Crestor Statin Prescription Drug removed Plaque Build-up in their Arteries

Crestor manufactured by AstraZeneca

This has been a landmark trial for the use of a cholesterol drug to reverse the buildup of plaque in coronary artery disease patients.

The Anglo-Swedish pharmaceutical company, AstraZeneca, reported this past Monday that their cholesterol drug, Crestor, has shown to reverse the atherosclerosis in a major clinical study.

The study was conducted over a two year period with 349 patients taking 40 milligrams of Crestor, a statin drug, once each day.  There were two-thirds of these patients that had shown regression of heart artery plaque build up when they were taking the maximum dose of Crestor. 

 

Crestor is one of the strongest statin drugs on the market for cholesterol and there has been concern by the Food and Drug administration for the serious side effects.  There are consumer groups lobbying to have it removed from the market.  The side effects are serious muscle problems and kidney damage.  Asians are especially at risk for complications with this medication.   

According to a news report by ABC News channel 7 in Los Angeles said that the Food and Drug Administration refused to remove the drug off the market.  Instead the Food and Drug Administration had put a warning of the possible side effects put on the label.

 

The study was funded by AstraZeneca PLC who is the manufacturer of Crestor.  Dr. Steven Nissen who is a cardiologist at a Cleveland Clinic led the research and first reported the results at the American College of Cardiology.  The complete report will be printed in the April 5th issue of the Journal of the American Medical Association.

The study showed that Crestor dramatically lowered LDL “bad” cholesterol.  The patient’s blood started at around 130 and went down to 60 milligrams per deciliter of blood.  The HDL “good” cholesterol went up slightly from 43 up to 49 at the end of the trial.

 

This study give hope to people that suffers from heart disease as this study shows that plaque in the arteries can be reversed.  It also should give incentive to everyone  and to know the importance of lowering their LDL “bad” cholesterol levels.  The researchers are not sure if the reversal will mean that there will be fewer heart attacks as it is too soon to know.

A previous article by Best Syndication wrote about a study that was able to lower cholesterol through diet modification.  Since there are potential side effects with cholesterol lowering medications, it would be optimal to work on the diet in combination with the prescription drugs to lower cholesterol levels.

How to lower Cholesterol by Diet

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Nicole Wilson
Best Syndication

Cholesterol Books at Amazon

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Copyright 2005 Best Syndication                                            Last Updated Saturday, July 10, 2010 09:48 PM