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High Blood Pressure – The sooner treated with Medication the less likely of developing Hypertension

March 14th, 2006

High Blood Pressure – The sooner treated with Medication the less likely of developing Hypertension

Blood Pressure Monitor

Early intervention of high blood pressure by treating with medication as well as dietary changes can help prevent the development of hypertension later on.  Adults that showed pre-hypertensive or high normal blood pressure (HNBP) had shown a benefit by early treatment with prescription drugs.

Pre-hypertension is still is has its health risks.  There is an estimated double the risk of having a heart attack or stroke compared with those that have normal blood pressure.

The research was first presented at today’s American College of Cardiology’s 55th Annual Scientific Session and will also be presented in the New England Journal of Medicine.  The lead researcher Stevo Julius, M.D., Professor Emeritus of Medicine and Physiology at the University of Michigan, Ann Arbor had conducted this four year trial called TROPHY.  Funding for the trial came from AstraZeneca who are the makers of ATACAND (candesartan cilexetil).


The trial study was set up to determine the safety and the potential benefits of treating patients early with prescription drugs when a persons blood pressure was 130 – 139 mm Hg over 85-89.  There were a total of 772 patients that participated in the trial.  The overall average blood pressure of the participants was 134/84.8.  They were randomly assigned either to take 16mg of candesartan or they took a placebo.  The participants had regular screenings to check for blood pressure both at home and in a clinic setting.  The participants were also educated on non-drug related blood pressure lowering techniques such as exercise and diet. 


There was a 15.6 percent lower risk for developing hypertension in the participants that took the prescription drug compared to those that took only the placebo the whole time.  The researchers believe that the drug treatment helped to slow down the blood-vessel changes that help raise blood pressure.

The official guideline for diagnosing hypertension is that the patient has to have blood pressure readings of 140 over 90 at three different doctor visits or the patient has blood pressure that was 160 over 100 at any one doctor visit.  The doctor seeing the patient should look for any possible organ damage or medical condition that would require treatment.


"Prehypertension is currently treated by lifestyle modification, but this form of treatment has had little effect on public health," said Stevo Julius, M.D. "It was therefore appropriate to investigate whether treatment with blood pressure-lowering drugs in this early phase of hypertension is feasible and whether it would slow down the transition from "prehypertension" to treatment-requiring hypertension."

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Nicole Wilson
Best Syndication

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Copyright 2005 Best Syndication                                            Last Updated Saturday, July 10, 2010 09:48 PM