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Prostate Cancer may stall Tumor growth with Raloxifene Drug Treatment

March 21st, 2006

Prostate Cancer may stall Tumor growth with Raloxifene Drug Treatment

Cancer Cells Dividing

Researchers from Cedars-Sinai found that a drug called Raloxifene may help in the treatment of men with prostate cancer.  Raloxifene is a drug that is currently on the market used to treat osteoporosis.  The complete report will be in the April 2006 issue of the British Journal of Urology International.

"We undertook this study because we desperately need new therapies for patients with advanced prostate cancer," said David B. Agus, M.D. who is the research director of the Louis Warschaw Prostate Cancer Center at Cedars-Sinai and also is the principal investigator of this study.


Prostate Cancer will kill approximately 35,000 men this year and is the leading cause of cancer of men in the United States.  It is estimated that one in six men will be diagnosed with prostate cancer some time in their lifetime.

Raloxifene is already approved by the FDA and is in the market.  It allowed researchers to go directly to a clinical trial with this drug.  The participants of the trial were given a daily oral dose of Raloxifene.  They were monitored on a regular basis for any changes in the prostate cancer.  They say some participants that took Raolxifene had shown signs that the prostate cancer tumor growth was stabilized by slowing and stopping its spread.


"It used to be that to show effectiveness through research studies, cancer drugs needed to shrink tumors by 50 percent," Agus said. "Now, the new way of thinking about the effectiveness of cancer drugs is whether they can slow cancer's growth, which ultimately may significantly benefit patients."

There still would need to be further randomized trials of Raloxifene to prove the effectiveness of treatment.

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