Prostate Cancer –
Eating Cruciferous Vegetables can help slow Tumor Growth
April 5th, 2006
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Cauliflower |
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Eating broccoli, cabbage, cauliflower and other cruciferous vegetables
have shown to stop human prostate cancer cells from growing in mice.
The study is being presented today at the American Association for
Cancer Research annual meeting in Washington, D.C.
"The contribution of diet and nutrition to cancer risk, prevention and
treatment have been a major focus of research in recent years because
certain nutrients in vegetables and dietary agents appear to protect the
body against diseases such as cancer," said Shivendra Singh, Ph.D. who
is the lead research and is also a professor of pharmacology and urology
at the University of Pittsburgh School of Medicine. "From epidemiologic
data, we know that increased consumption of vegetables reduces the risk
for certain types of cancer, but now we are beginning to understand the
mechanisms by which certain edible vegetables like broccoli help our
bodies fight cancer and other diseases."
This study looked at phytochemicals that are found in cruciferous
vegetables. These phytochemicals are called isothiocyanates (ITCs).
The ITCs are made when these vegetables are cut or chewed. The
researchers found that it was this phenethyl-ITC (PEITC) the compound
that caused the human prostate cancer cells from growing. The amounts
of the PEITC needed for a person to achieve this benefit could be
accomplished with dietary intake of eating the cruciferous vegetables.
The researchers feed PEITC to mice who had grafted human prostate
tumors. They did this treatment daily for 31 days. They also had a
control group that had the tumor but was not fed PEITC. The mice that
did not have the PEITC had on average tumors that were 1.9 times more in
volume. The researchers also found that a protein called Bax also was
present with the PEITC which also helped in the cancer cell death.
"Our next step is to design clinical trials to determine the efficacy of
PEITC for prostate cancer prevention in men," said Dr. Singh.
Nicole Wilson
Best SyndicationBooks on Cancer
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