High Blood Pressure and Renal Disease –
Possible New Approach to treating Hypertension and avoiding Kidney
April 6th, 2006
from the University of Florida tested gene therapy by using RNA
interference for treatment of high blood pressure. They were able to
stop the high blood pressure from increasing in mice and also were able
to prevent kidney damage. The study was first reported in the online
journal called Gene Therapy.
A corrective gene
was injected into mice that were exposed to cold weather. The treated
mice had blood pressure that did not get worst and their kidney had
almost no damage. The cold weather caused the mice to have constricted
blood vessels. By constricting the blood flow the kidneys would be
overloaded with hormones that could cause damage.
Cold weather can
increase blood pressure and more heart attacks and strokes happen during
the cold winter months. That is why they studied 3 different groups of
mice that were kept in an environment of 44 degree Fahrenheit for a
total of five weeks. They measured the blood pressure of the mice for a
3 week period of time.