Diabetes Type 1 – Potential Cure for
Insulin Dependent Juvenile Diabetes
April 22nd, 2006
A team of
researchers from the La Jolla Institute for Allergy and Immunology (LIAI)
have made a major discovery that could lead to a potential cure for type
1 diabetes. The research team was led by Matthias von Herrath, M.D., an
internationally recognized expert on the molecular basis of type 1
diabetes has plans for human clinical trials to begin later in the year.
The treatment in
this study used a combination to reverse the recent onset of type 1
diabetes in the majority of lab animals that they tested. Type 1
diabetes is caused by an immune system that attacks the pancreas which
causes a deficiency of insulin production. Type 2 diabetes is usually
caused by being obese or overweight. The report was first published in
the Journal of Clinical Investigation.
The two therapies
the researchers were using are called anti-CD3 antibody and proinsulin
peptide. There currently are human trials with these treatments, but on
an individual basis. The results so far for the human trials with these
chemicals on an independent basis were not as effective in the
treatments compared to the mice studies. The researchers hope that
combining the treatments in a human trial will be successful.