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Weight Loss Hormone may help Obese Eat less and Move More

April 26th, 2006

Weight Loss Hormone may help Obese Eat less and Move More

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Researchers found that supplementing a hormone found in the gut can help stall an appetite and at the same time increase activity.  This study was first pre-published in the online version of the International Journal of Obesity.

The hormone is called oxyntomodulin.  Professor Steve Bloom, from Imperial College London, who led the research, said: "The discovery that this hormone has a double effect, increasing energy expenditure as well as reducing food intake, could be of huge importance. When most people diet, this produces a reduction in activity, which is probably an adaptive trait to conserve energy during times of famine. However this does make it especially difficult for obese individuals trying to lose weight. In contrast oxyntomodulin decreases calorific intake, but actually increases energy expenditure, making it an ideal intervention for the obese."


Researchers at the Imperial College London gave oxyntomodulin injections to fifteen overweight participants that had not other health problems.  The participants, both male and female were between ages 23 and 49.  They measured how much food they ate and activity level after they received the hormone.  Some of the participants were used a control group and were given saline solution injections instead of the hormone.

The study lasted for four days.  The first day the researchers gave the injections and watched closely the amount of food that they were eating and counted the amount of calories they consumed.  For the next two days the participants were in their own living environment and they gave their own injection of the hormone before each meal (3 times a day).  They returned back to the hospital on the 4th day to have the researchers measure the amount of energy that they had available.


The results of the study showed that the hormone injected participants on the first meal ate on average 128 kcal (17.4% less).  The researchers report that the hormone injected participants increased their energy expenditure by an average of 143 kcal (26.2 %).  They hormone group also had an overall average of 0.5% weight loss.

Professor Bloom said, "This discovery could provide doctors with a whole new way to treat the current obesity epidemic. We need to get away from the focus on food and start to think about how to increase exercise. The question is how to make people enjoy taking exercise and how to encourage them to do it spontaneously.

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Nicole Wilson
Best Syndication

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Important:  The material on Best Syndication is for informational purposes only and is not a substitute for medical advice or treatment for any medical conditions. You should promptly seek professional medical care if you have any concern about your health, and you should always consult your physician before starting a fitness program.

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Copyright 2005 Best Syndication                   Last Updated Saturday, July 10, 2010 09:48 PM