Weight Loss
Hormone may help Obese Eat less and Move More
April 26th, 2006
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Researchers found
that supplementing a hormone found in the gut can help stall an appetite
and at the same time increase activity. This study was first
pre-published in the online version of the International Journal of
Obesity.
The hormone is
called oxyntomodulin. Professor Steve Bloom, from Imperial College
London, who led the research, said: "The discovery that this hormone has
a double effect, increasing energy expenditure as well as reducing food
intake, could be of huge importance. When most people diet, this
produces a reduction in activity, which is probably an adaptive trait to
conserve energy during times of famine. However this does make it
especially difficult for obese individuals trying to lose weight. In
contrast oxyntomodulin decreases calorific intake, but actually
increases energy expenditure, making it an ideal intervention for the
obese."
Researchers at the
Imperial College London gave oxyntomodulin injections to fifteen
overweight participants that had not other health problems. The
participants, both male and female were between ages 23 and 49. They
measured how much food they ate and activity level after they received
the hormone. Some of the participants were used a control group and
were given saline solution injections instead of the hormone.
The study lasted
for four days. The first day the researchers gave the injections and
watched closely the amount of food that they were eating and counted the
amount of calories they consumed. For the next two days the
participants were in their own living environment and they gave their
own injection of the hormone before each meal (3 times a day). They
returned back to the hospital on the 4th day to have the
researchers measure the amount of energy that they had available.
The results of the
study showed that the hormone injected participants on the first meal
ate on average 128 kcal (17.4% less). The researchers report that the
hormone injected participants increased their energy expenditure by an
average of 143 kcal (26.2 %). They hormone group also had an overall
average of 0.5% weight loss.
Professor Bloom
said, "This discovery could provide doctors with a whole new way to
treat the current obesity epidemic. We need to get away from the focus
on food and start to think about how to increase exercise. The question
is how to make people enjoy taking exercise and how to encourage them to
do it spontaneously.”
Nicole Wilson
Best Syndication
Books on Dieting
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