"Our results indicate that these
mice are extremely sensitive to insulin and, consequently, they are very
effective in metabolizing glucose at the level of the liver and the
muscles," said André Marette. SHP-1 slows down the breakdown of insulin
in the liver. "This could explain the increase in the insulin
concentrations of certain metabolic disorders associated with obesity,"
he further explained.
"The results of Andre Marette and
his team represent an important step in the development of a new
therapeutic approach in the fight against diabetes. Advances in the
treatment of diabetes are needed to improve the lives of the more than
two million Canadians already affected by it and the many more who will
develop the disease in the years to come. The study is a perfect example
of the potential benefits of investing in health research," said Dr.
Diane Finegood who is based in Vancouver and is the Scientific Director
of the CIHR Institute of Nutrition, Metabolism and Diabetes.
"By inhibiting the activity of
SHP-1, it would perhaps be possible to restore better control of blood
glucose," said professor Marette.
The concerns with blocking SHP-1
would be for any potential harm to the immune system. At this time it
is not known if blocking the protein would be detrimental or not.
Further researcher would need to be completed to know how safe it would
be to block SHP-1. There still needs to be more research to determine
if SHP-1 is involved in the development of type 2 diabetes in humans.
"Good glucose control is essential
for managing diabetes and preventing the debilitating complications
associated with diabetes," said Dr. Paula Dworatzek, Senior Research
Associate, Canadian Diabetes Association. "We congratulate Dr. Marette
and his team for these initial findings, which will pave the way for his
team and others to pursue a potential new therapy in the management of
diabetes."
Nicole Wilson
Best Syndication
Books
on Diabetes
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