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Lung Cancer – Tumor growth increases with loss of a Protein

May 31st, 2006

Lung Cancer – Tumor growth increases with loss of a Protein


Zafira Castaño who is a researcher and Doctor in Biochemistry from the University of Navarra in Spain, discovered a connection between lower levels of αCP4 protein in early stages of lung cancer and may help make tumors grow.

Castaño noticed that these αCP4 protein cells are found on tissue cells within a healthy lung.  However in a lung that was in first phase of cancer there was a loss of this protein.  The αCP4 protein was also lacking in 67% of the tumors as well.

To confirm the findings Castaño took samples of various cellular lines from different kinds of lung tumors.  She then introduced a series of the αCP4 protein to the tumor tissues to see what would result.  Some of the tumors responded to the introduction of the protein.  Tumor proliferations were reduced with malignant tumors of large cells she noticed that their ability to grow was reduced. 


Hopefully this research will help in the treatment for early stages of lung cancer in the future.  There still is a need to better detect lung cancer before is develops into a late stage which is often deadly.

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