Type 2 Diabetes –
Elevated levels of RBP4 early indication of Insulin Resistance
June 15th, 2006
Exercise can help
lower RBP4 levels
A recent study
found that increased levels of retinol binding protein 4 (RBP4) molecule
helps predict the early stage of insulin resistance which is the one of
the major reasons why most people develop type 2 diabetes and
cardiovascular disease. This study led by researchers from Beth Israel
Deaconess Medical Center (BIDMC) was first reported in the June 15th
issue of The New England Journal of Medicine (NEJM).
It may become
possible to develop anti-diabetic therapies that lower RBP4 levels. By
measuring for elevated levels of RBP4, this could be used as a
diagnostic tool to assess people’s risk for developing diabetes before
the disease becomes onset.
"Type 2 diabetes
is a rapidly increasing epidemic in the Western world," said senior
author Barbara Kahn, MD., who is Chief of the Division of Diabetes,
Endocrinology and Metabolism at BIDMC and is also Professor of Medicine
at Harvard Medical School. "Since it is now occurring even in childhood,
predictions indicate that it could shorten lifespan in the U.S. for the
first time in more than a century."