Menopause Hot Flashes could be helped by taking
June 20th, 2006
been used to help in the treatment for menopausal hot flashes.
Gebapentin is used to treat migraine headaches. Pfizer, who is the
manufacturer of gabapentin, doesn't comment on off label use of drugs.
Using gebapentin for treating menopausal hot flashes is an off label
use, but has been used as an alternative to the treatment of hot flashes
compared to estrogen hormone therapy.
One research study
looked at the alternatives therapies available for the treatment of hot
flashes. The researcher concluded with the following statement:
increasing interest in therapies for menopausal hot flashes that avoid
use of estrogen, the efficacy and safety of other options currently are
not well supported. The SSRIs or SNRIs, clonidine, and gabapentin
provide some evidence of efficacy. However, effects are less than those
for estrogen therapy, few trials have been published and most have
methodological deficiencies, and generalizability beyond the small
clinical populations studied could be limited. Adverse effects and cost
may prohibit use for many women. Although these therapies may be most
useful for highly symptomatic women who cannot take estrogen, they are
not optimal choices for most women,” said Heidi D. Nelson, M.D., M.P.H.,
of the Oregon Health and Science University and Providence Health
System, Portland, Oregon in a study that was first reported in the May 3rd
issue of JAMA.