"Non-dietary
therapies that allow celiac patients to safely incorporate
low-to-moderate levels of gluten into their daily diet would be of
considerable benefit," said the lead author, Dr. Chaitan Khosla, from
Stanford University and Celiac Sprue Research Foundation. "Having
demonstrated earlier that certain types of enzymes can detoxify gluten,
our laboratory set out to devise an optimal oral enzyme therapy for
celiac sprue by borrowing from nature. In germinating barley seed,
gluten serves as a nutritious storage protein that is efficiently
digested by enzymes. One enzyme, EP-B2, plays a crucial role in this
process by breaking gluten proteins after glutamine residues, which
comprise one-third of all amino acid residues in gluten."
The scientists in
this study were able to simulate the stomach acidic conditions and using
the EP-B2 enzyme was able to efficiently digest gluten protein. The
gluten was digested to a point where no triggers for a celiac
inflammation would occur. The scientists conducted a second study with
a double enzyme therapy which was used as a way of detoxifying the
gluten.
The combination
included the EP-B2 enzyme alone with another enzyme called PEP. While
separately the PEP or the EP-B2 where not able to detoxify the gluten
quickly enough to prevent inflammatory response, however when the two
enzymes where combined, the gluten immunotoxicity was removed within ten
minutes. These tests were completed in a simulation of gastric duodenal
conditions.
What was
accomplished was a two part series in digesting and breaking down the
gluten. The EP-B2 enzyme broke down the gluten into small pieces while
the PEP stepped into detoxify under duodenal conditions.
"Our results
suggest that recombinant EP-B2 should be effective as supportive therapy
to help celiacs cope with the 'hidden' gluten in everyday life, and that
a two-enzyme cocktail containing PEP and EP-B2 may even allow celiacs to
resume a more normal diet in the future," offers Dr. Khosla.
Nicole Wilson
Best Syndication
Books on Digestive Enzymes
Keywords and misspellings: seliack celiack glutin
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