Bladder Cancer –
Scientists demonstrates how a protein helps to spread Cancer
July 17th 2006
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Courtesy of
Sandia National Laboratories |
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Scientists from
the Jefferson Medical College and Jefferson’s Kimmel Cancer Center
believe that they have found a protein called proepithelin that helps
aid in the spread of bladder cancer. The study was first reported in
the July 15th issue of Cancer Research.
"The fact that
proepithelin doesn't appear to strongly promote cell proliferation, but
instead promotes migration and invasion – two crucial steps leading to
metastasis – suggests that it could be critical for the passage of a
cancer from a noninvasive to an invasive phenotype," said Andrea
Morrione, Ph.D., research assistant professor of urology at Jefferson
Medical College of Thomas Jefferson University and Jefferson's Kimmel
Cancer Center in Philadelphia.
Proepithelin helps
in the development of cancer, it helps aid in cell movement and it also
plays a role in the tumor formation. Higher than normal levels of
proepithelin, are often found in people who have breast, ovarian, and
renal cancers. This protein is also found in cases of deadly brain
cancer called glioblastomas.
In this study, the
scientists demonstrated how 5,637 bladder cancer cells were affected by
the presence of proepithelin. The proepithelin helped increase the
migration of the bladder cancer cells. It also helped to stimulate
wound closure and invasion which contributes to the spread of cancer.
The molecular pathway in bladder cancer formation was turned on with
proepithelin with a common MAP kinase pathway.
By further
researching proepithelin, new tests could be developed to potentially
measure if bladder tumors metastasis. Bladder tumors often reoccur, and
are difficult to treat. Developing a non-invasive test may help predict
if tumors are present and may help in early treatment, which would in
turn offer better survival rates.
According to the
American Cancer Society, there is an estimated 61,420 new cases of
bladder cancer in the United States this year. It is the fifth most
common type of cancer in this country.
Nicole Wilson
Best Syndication
Books on Bladder Cancer
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