Bladder Cancer –
Scientists demonstrates how a protein helps to spread Cancer
July 17th 2006
Sandia National Laboratories
the Jefferson Medical College and Jefferson’s Kimmel Cancer Center
believe that they have found a protein called proepithelin that helps
aid in the spread of bladder cancer. The study was first reported in
the July 15th issue of Cancer Research.
"The fact that
proepithelin doesn't appear to strongly promote cell proliferation, but
instead promotes migration and invasion – two crucial steps leading to
metastasis – suggests that it could be critical for the passage of a
cancer from a noninvasive to an invasive phenotype," said Andrea
Morrione, Ph.D., research assistant professor of urology at Jefferson
Medical College of Thomas Jefferson University and Jefferson's Kimmel
Cancer Center in Philadelphia.
in the development of cancer, it helps aid in cell movement and it also
plays a role in the tumor formation. Higher than normal levels of
proepithelin, are often found in people who have breast, ovarian, and
renal cancers. This protein is also found in cases of deadly brain
cancer called glioblastomas.