Home  Top Stories  Sports  Entertainment  Health News  Business  Personal Finance 
Real Estate  Business Finance  Insurance  Consulting 
Tax News  Forum



Featured Articles








Weight Loss - Why some Diet Supplements help Suppress Appetite

July 19th, 2006

Weight Loss - Why some Diet Supplements help Suppress Appetite

 Appetite Controlled by serotonin

Scientists have new understandings why some weight loss drugs work by enhancing the serotonin levels in the brain.  The diet drugs that have these mood boosting effects on serotonin include sibutramine (marketed as Meridia), and fenfluramine.  Fenfluramine has been recalled because of the combination with dexfenfluramine, marketed as fen-phen because of the possibility of fatal heart valve abnormalities.

How does serotonin suppress appetite?  The group of researchers, led by Michael Cowley of Oregon Health and Science University conducted research on mice to further investigate how serotonin works with the hypothalamus.  They traced the receptors for serotonin and they saw that particular neurons were expressed in this circuitry which directly changed the mice food intake and body weight. They further found a protein called AgRP that stimulated appetite and another protein called áMSH that curbs appetite.  These AgRP protein was reduced when the serotonin and drugs that affected serotonin was present while at the same time the áMSH protein was increased reducing the appetite.


The researchers tested mice to see what effects of the various drugs that enhance or interfere with serotonin would have on their eating behavior.  The drugs helped to disrupt the function of receptors by a substance called melancortin.  Melanocoritin has been known to act for receptors of the proteins AgRP and áMSH which control a person’s appetite. 

Another receptor called melanocortin receptor-4 was identified by the researchers as a critical target of the serotonin pathway, which seems to be the central location for appetite regulation.

The study was first reported in the July 20th issue in Neuron.  Other researchers that have contributed to this study was Joel Elmquist of University of Texas Southwestern Medical Center at Dallas and formerly of Beth Israel Deaconess Medical Center and Harvard Medical School, and Lora K. Heisler of the University of Cambridge and formerly of Beth Israel Deaconess Medical Center and Harvard Medical School.

Comment on this Article at our Forum

Submit your own Article

Diet and Fitness Special Topic

  RSS Feed to our Diet & Fitness News

  RSS Feed to our health News

  RSS Feed to all of our News

Add to Google Add to My AOL
Add to My Yahoo! Subscribe with Pluck RSS reader
Subscribe in NewsGator Online
Add this feed to Your C-Net
Subscribe in Bloglines Subscribe in Rojo

Nicole Wilson
Best Syndication

Books on Dieting

Keywords and misspellings: appetite apetite supressant diet aid suppress hunger pains diet pills medication apetit reduce hunger eat less food how to decrease hunger pains alternatives remedies deit pills hoodia rimonabant rinomabant rinonant rinomabent wieght watchers

Important:  The material on Best Syndication is for informational purposes only and is not a substitute for medical advice or treatment for any medical conditions. You should promptly seek professional medical care if you have any concern about your health, and you should always consult your physician before starting a fitness program.
Web BestSyndication.com

About   Contact   Site Map

Copyright 2005 Best Syndication                   Last Updated Saturday, July 10, 2010 09:47 PM