Common Drug Used
During Heart Surgery is Dangerous - Aprotinin (Trasylol) causes Kidney -
Heart Attacks and Stokes
A commonly used drug during heart surgery could cause serious
complications including kidney damage, an increased risk of hear attack,
heart failure and stroke. The drug called aprotinin (the brand name is
Trasylol), is used to control bleeding on as many as 1 million heart and
bypass surgery patients per year.
Aprotinin doubles the risk of kidney damage but also increases the risk
of heart attack by 48%. Heart failure risk is also increased by 109%
and stroke by 181%. The study looked at 4,400 patients.
There are safer alternatives. In fact the generic alternatives cost a
tenth as much as aprotinin and are almost as effective, according to a
report in the LA Times. Aprotonin is derived from cow lungs and was
approved by the Food and Drug Administration (FDA) in 1993.
The research is reported in this issue of the New England Journal of
Medicine (NEJM). According to that report “the observed association
between aprotinin and serious end-organ damage indicates that continued
use is not prudent, whereas the less expensive generic medications.”
The medication, according to a report published in the Seattle Times,
has caused more than 11,000 patients worldwide “to need kidney dialysis
each year”. With safer alternatives, doctors are advised to not use the
drug except in unusual circumstances.
Bayer, the manufacturers of the drug claims in a statement that it has
not yet analyzed the study, but their own test results were not
consistent with the NEJM study. The FDA is reviewing the research and
“will make recommendations for best use as soon as possible."
Best Syndication Staff Writer
Books on Heart Disease
Keywords and misspellings: disease bypass
surgery bipass sergery sergury tralisol traylosol asprotinin apratinin