Combination of Two
Drugs Work Best On Migraine Headaches – Combine Sumatriptan and Naproxen
– Trexima is Planned Brand Name
April 6th 2006
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Migraines |
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A combination of sumatriptan and a nonsteroidal anti-inflammatory
medicine, naproxen sodium, the active ingredient in Aleve, work better
than either drug taken separately. Harvard Scientists say that this
suggests there are two separate brain pathways involved in triggering
migraines.
The research involved two studies, combining more than 2,800 migraine
sufferers. Within two hours after taking the combination drug, 65
percent said their migraine pain was relieved, compared with 55 percent
on sumatriptan alone and 44 percent of that on naproxen.
The data was presented at the 58th Annual Meeting of the American
Academy of Neurology (AAN). Data from one “long term” study over one
year prompted researchers to say that combining the two drugs into a
single tablet was well tolerated. The single tablet is currently under
review by the Food and Drug Administration (FDA) under the proposed
brand name Trexima.
The researchers say that taking the single pill led to a significant
reduction in mean total lost workplace productivity versus placebo,
sumatriptan or naproxen sodium alone. The one-year study of 565
patients involved treating nearly 24,500 migraine attacks (an average of
five attacks per month) with the single tablet found no new or
unexpected adverse events. The most common treatment-related adverse
events reported within 24 hours of taking the single tablet were nausea
(6%), dizziness (3%), muscle tightness (3%), dyspepsia (2%) and
paresthesia (2%).
The other study found that triptan alone could not block the central
neuronal sensitization that results from stimulation of the main sensory
nerve (trigeminal nerve), but naproxen was effective at suppressing
central neuronal sensitization.
There are about 29.5 million people who suffer from migraine headaches
in the US, according to National Headache Foundation (NHF). The
foundation says that many migraines can be brought on by foods, and they
recommend keeping a diary of what you ate before each migraine. This
can help in building a list of foods to avoid, at least for those who
have migraines triggered by food.
By Dan Wilson
Best Syndication
Books about Pain
Keywords and misspellings:
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