Replacement Therapy HRT Safer For Short Term - Significant Breast Cancer
Risk in Long Term Users - 20 Years
May 9th 2006
An article in this issue of Archives of Internal Medicine suggests that
the long-term use of oestrogen-only hormone replacement therapy (HRT)
does increase the risk of breast cancer. The authors say that
“short-term unopposed estrogen use does not seem to increase breast
The researchers used data from the Nurses’ Health Study. They observed
11,508 postmenopausal women who had a hysterectomy and reported
information on estrogen use at baseline (1980). The study population
expanded every two years until a total of 28,835 women were included in
the final follow-up period between the years 2000 and 2002.
The women were assessed using self-reported data on biennial
questionnaires. The results seem to conflict with a Stanford University
study just last month that found no evidence of any increased risk in
women who used the therapy for up to seven years. But does it conflict?