Join Now!
Home  Top Stories  Sports  Entertainment  Health News  Business  Personal Finance 
Real Estate  Business Finance  Insurance  Consulting 
Tax News  Forum
 

Writers






 


Featured Articles







BUSINESS



 




How much should you be saving on Health Insurance?

Cooking-free  gourmet frozen meals

120 x 60 Firm Tummy


Search:

 

Health

 

New Study Question High Dosage Statin Use - Side Effect Risk May Outweigh Benefits - High Cholesterol - British Medical Journal Article 

June 3rd 2006

New Study Question High Dosage Statin Use - Side Effect Risk May Outweigh Benefits - High Cholesterol - British Medical Journal Article

Statin Drug Questions

A new study published in the British Medical Journal (BMJ) questions whether more aggressive treatment of cholesterol is prudent.  By aggressive, they mean therapy to lower low density lipoprotein (LDL or bad cholesterol) cholesterol concentrations to less than 1.81 mmol/l.  The researchers said that the U.S. National Cholesterol Education Program’s new recommendations for cholesterol levels “might therefore put most of the Western world’s adult population on statin therapy.”

The study questions the wisdom of higher doses of statin drugs.  In the treating to new targets (TNT) trial, the US researchers compared a low and high dose of the same statin, and found that not even 80 mg atorvastatin was able to lower mean low density lipoprotein cholesterol below 1.81mmol/l.  The previous research said “Intensive lipid lowering therapy with 80 mg of atorvastatin per day in patients with stable CHD (coronary heart disease) provides significant clinical benefit.”  Evidently they were not worried about the serious side effects (page 1331 BMJ).

 

The new research suggests that the overall mortality was not reduced because the small number of cardiovascular deaths in the 80mg atorvastatin group was offset by increased deaths from other causes leaving a benefit of 5% fewer non-fatal cardiovascular events.  There was “deficient information” about the serious side effects.  Some of these side effects could result in death.

This new research from Europe suggests that increasing the dosage of statin drugs (sometimes more than 8 times higher than the dosages used today), would result in significantly more adverse side effects from the drugs.  This may outweigh any benefits seen by lowering the heart disease risk. 

 

Incredibly, statin use can increase the risk of heart failure.  Other problems associated with the drugs include muscle and liver problems, mental and neurological symptoms, and cancer.

More research is needed to determine overall mortality rates associated with higher dosages.  But until those studies are done, these researchers question the idea of giving many more people statin drugs.  Study Authors Uffe Ravnskov, Paul J Rosch, Morley C Sutter, Mark C Houston

 
 
Comment on this Article at our Forum

Submit your own Article

Lung and Heart News

  RSS Feed to our Heart/Lung News

  RSS Feed to health News

  RSS Feed to all of our News

Add to Google Add to My AOL
Add to My Yahoo! Subscribe with Pluck RSS reader
Subscribe in NewsGator Online
Add this feed to Your C-Net
Subscribe in Bloglines Subscribe in Rojo

Dan Wilson
Best Syndication

Books on Heart Disease

Keywords and misspellings:  colesterol cholesteral stantin stantoncoranary micro-vascular disfunction iscemic iskemic ishcemic ishcemia angiograf blood presure stroke embolism lipitor zocor lipitar lipator


Important:  The material on Best Syndication is for informational purposes only and is not a substitute for medical advice or treatment for any medical conditions. You should promptly seek professional medical care if you have any concern about your health, and you should always consult your physician before starting a fitness program.
Google
 
Web BestSyndication.com

About   Contact   Site Map

Copyright 2005 Best Syndication                   Last Updated Saturday, July 10, 2010 09:51 PM