Join Now!
Home  Top Stories  Sports  Entertainment  Health News  Business  Personal Finance 
Real Estate  Business Finance  Insurance  Consulting 
Tax News  Forum



Featured Articles






DNA Vaccine Developed For Alzheimer's Disease - Japanese Researchers Say Genetic Based Vaccine Could Reverse Plaque Buildup in Brain

June 14th 2006

DNA Vaccine Developed For Alzheimer's Disease - Japanese Researchers Say Genetic Based Vaccine Could Reverse Plaque Buildup in Brain


Japanese researchers say that they have promising new results with mice studies that may benefit Alzheimer’s disease patients.  They have been able to cut levels of key amyloid proteins thought to cause the disease, by up to 50% in some parts of the brain by using a DNA vaccine.

The over-production of amyloid proteins are thought to trigger symptoms of Alzheimer's by forming clumps that litter the brain, according to the BBC.  Previous research has shown that it is possible to stimulate the immune system of mice to attack these plaques, if they are immunized with amyloid protein.  But when this was done in humans the immune response was so great that the brain began to swell. The clinical trial for a vaccine had to be called off in 2003 after 18 of the 298 patients developed swelling in their brains.


Now the researchers are trying to mobilize the immune system response in a less aggressive manner.  They hope this avoids brain swelling while still destroying the plaque. 

In the earlier trial, doctors speculated that exposing the human immune system to small amounts of beta-amyloid could cause it to destroy the "rogue" protein. Beta-amyloid is a protein thought to initiate the buildup of plaques in the brain that is the primary finding in Alzheimer's disease, according to

The team at the Tokyo Metropolitan Institute for Neuroscience has been working on a technique that would stimulate the body to produce smaller amounts of the amyloid protein.  The mice are injected with naked DNA that codes for these proteins.  This may be a better approach than relying on a virus to get the gene-based vaccine to the cell.


They say this has a more gentle effect on the immune response.  The DNA has also been designed so that it can not replicate by incorporating itself into the human genome. 

The scientists report that the latest vaccine reduced the deposition of amyloid proteins by between 15.5% and 38.5% compared with untreated mice.  Also the deposition in the cerebral cortex and hippocampus was reduced 40%-50%.

It is hoped this DNA vaccine will provide a low cost and effective treatment for Alzheimer’s disease.  Currently there is no cure for the disease.  Lead researcher, Dr. Yoh Matsumoto, said that the vaccine could be a milestone provided it does not cause side effects like the other vaccines.


It is important to note that not all scientists agree that the overproduction of amyloid-beta peptides is the main cause of Alzheimer’s disease.  The findings appear in this week's issue of the Proceedings of the National Academy of Sciences.

Comment on this Article at our Forum

Submit your own Article

The Mind and Psychology News

Genetics Special Topic and News

  RSS Feed to our Genetics News

  RSS Feed to our Alzheimer's News

  RSS Feed to our health News

  RSS Feed to all of our News

Add to Google Add to My AOL
Add to My Yahoo! Subscribe with Pluck RSS reader
Subscribe in NewsGator Online
Add this feed to Your C-Net
Subscribe in Bloglines Subscribe in Rojo

Dan Wilson
Best Syndication

 Books on the Mind

Keywords and Misspellings:  Anti-depressant anti-depresant vagel shock treatment seratonin rueptake

Important:  The material on Best Syndication is for informational purposes only and is not a substitute for medical advice or treatment for any medical conditions. You should promptly seek professional medical care if you have any concern about your health, and you should always consult your physician before starting a fitness program.

About   Contact   Site Map

Copyright 2005 Best Syndication                   Last Updated Saturday, July 10, 2010 09:51 PM