Alzheimer's - High
Estrogen Levels Linked To Dementia – Netherlands Study of Older Hawaiian
Men – No Association Found with Testosterone
July 24th 2006
Researchers from the Netherlands have found a link between high estrogen
levels and dementia in older men. Their data came from a group of 2974
Japanese-American men aged 70 to 91 who participated in the
Honolulu-Asia Aging Study. The baseline fasting blood samples were
drawn between 1991 and 1993, at which time levels of testosterone and
estradiol, the major estrogen in humans were measured.
None of the participants had signs of dementia at the beginning of the
study. The researchers measured cognitive decline or dementia in all
the participants in 1994-1996 and 1997-1999 using the Cognitive
Abilities Screening Instrument (CASI). They collected physical,
demographic and medical information at each exam.
Of the 2300 participants who completed the study, 223 were diagnosed
with incident dementia during the follow-up period. There were 134 men
who developed Alzheimer's disease, and 44 developed vascular dementia.