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Omega-3 Fatty Acids (Fish) Lowered PSA 77 Percent In Lab Study - Also Lowered Prostate Cancer Tumor Growth by 22 % - Ratio of Omega-6

August 1st 2006

Omega-3 Fatty Acids (Fish) Lowered PSA 77 Percent In Lab Study - Also Lowered Prostate Cancer Tumor Growth by 22 % - Ratio of Omega-6

Prostate

Scientists from UCLA say that by modifying the typical Western diet to include more fish and less red meat could reduce the prostate cancer growth rate.  The diet requires eating more omega-3 and less omega-6 fatty acids.  This is the first study to show the impact of diet on lowering an inflammatory response known to promote prostate cancer tumor progression.

They believe this finding may lead to a new treatment or aid in the treatment of prostate cancer.  Omega-6 acids come from corn, safflower oils and red meats which are the predominantly the source of polyunsaturated fatty acids in the Western diet.  The omega-3 acids come primarily from cold-water fish like salmon, tuna and sardines.

 

Dr. William Aronson says "Corn oil is the backbone of the American diet. We consume up to 20 times more omega-6 fatty acids in our diet compared to omega-3 acids."  Aronson is the principal investigator and a professor in the department of urology at the David Geffen School of Medicine at UCLA and a researcher with UCLA's Jonsson Cancer Center.

Aronson went on to say "This study strongly suggests that eating a healthier ratio of these two types of fatty acids may make a difference in reducing prostate cancer growth, but studies need to be conducted in humans before any clinical recommendations can be made."

 

So far the scientists have used mice for their studies. Researchers fed one group of mice a diet comprised of 20 percent fat with a healthy one-to-one ratio of omega-6 to omega-3 fatty acids. A second group of mice were fed the same diet but with the fat derived from mostly omega-6 fatty acids.

The study showed that tumor cell growth rates decreased by 22 percent and PSA levels were 77 percent lower in the group receiving a healthier balance of fatty acids compared with the group that received predominantly omega-6 fatty acids.

The most likely mechanism for the tumor reductions, according to researchers, was due to an increase of the prostate tumor omega-3 fatty acids DHA and EPA and a lowering of the omega-6 acid known as arachidonic acid. These three fatty acids compete to be converted by cyclooxgenase enzymes (COX-1 and COX-2) into prostaglandins, which can become either pro-inflammatory and increase tumor growth, or anti-inflammatory and reduce growth.

 

The researchers found that pro-inflammatory prostaglandin (PGE-2) levels were 83 percent lower in tumors in the omega-3 group than in mice on the predominantly omega-6 fatty acid diet, demonstrating that higher levels of DHA and EPA may lead to development of more anti-inflammatory prostaglandins.

"This is one of the first studies showing changes in diet can impact the inflammatory response that may play a role in prostate cancer tumor growth," Aronson said. "We may be able to use EPA and DHA supplements while also reducing omega-6 fatty acids in the diet as a cancer prevention tool or possibly to reduce progression in men with prostate cancer."

They are offering men a chance to join a clinical trial who are undergoing prostate removal due to cancer.  They want to compare the effects of a low-fat diet using omega-3 supplements. 

In addition, Aronson said that further study might show that COX-2 inhibitors or non-steroidal anti-inflammatories (NSAIDS) combined with omega-3 supplements also may lower the inflammatory response in prostate cancer development.  

 
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Copyright 2005 Best Syndication                   Last Updated Saturday, July 10, 2010 09:51 PM