Join Now!
Home  Top Stories  Sports  Entertainment  Health News  Business  Personal Finance 
Real Estate  Business Finance  Insurance  Consulting 
Tax News  Forum



Featured Articles



Cooking-free  gourmet frozen meals

120 x 60 Firm Tummy






Leukemia Cancer Drugs May Cause Heart Failure - Gleevec and Other Tyrosine Kinase Inhibitors Toxic and May Cause Problems

July 23rd 2006

Leukemia Cancer Drugs May Cause Heart Failure - Gleevec and Other Tyrosine Kinase Inhibitors Toxic and May Cause Problems


New drugs used to treat leukemia, including Gleevec, may cause serious heart damage, according to U.S. researchers.  The researchers say that people taking the medication should continue to take it, but should also be closely monitored for heart damage.

The researchers from Jefferson Medical College in Philadelphia, Tufts University School of Medicine in Boston, University of Texas released the caution of Sunday, after they found evidence that treatment caused heart failure in 10 patients.  They say that people taking other drugs in the same class, called tyrosine kinase inhibitors, may also be at risk for heart damage.

The drugs have been very successful in treating chronic myelogenous leukemia or CML, in most patients. They have found that 80 to 90 percent of the patients taking the drug were cancer free for at least five years.  The drugs have also been successful in treating a rare form of stomach cancer called gastrointestinal stromal tumors or GIST.


Thomas Force, who led the investigation, said “"Gleevec is a wonderful drug and patients with these diseases need to be on it. We're trying to call attention to the fact that Gleevec and other similar drugs coming along could have significant side effects on the heart and clinicians need to be aware of this. It's a potential problem because the number of targeted agents is growing rapidly."

The researchers tested the drug in lab dishes and found that it appears to be toxic to heart cells.  Also, mice treated with Gleevec developed left ventricular dysfunction.  This is a key symptom for heart failure.  Novartis, the maker of Gleevec said the cases of heart failure were rare.


Force said “While the cancer is treated effectively, there will be some percentage of patients who could experience significant left ventricular dysfunction and even heart failure from this.”  Heart failure will kill half of the patients within 5 years.

Novartis said that patients can be successfully treated with two drugs that can help treat the heart failure.  These drugs, called ACE inhibitors and carvedilol, can be used as a treatment, but the prognosis for heart failure remains poor.   

Comment on this Article at our Forum

Submit your own Article

Cancer Prevention and Treatments

  RSS Feeds to Cancer News

  RSS Feed to our health News

  RSS Feed to all of our News

Add to Google Add to My AOL
Add to My Yahoo! Subscribe with Pluck RSS reader
Subscribe in NewsGator Online
Add this feed to Your C-Net
Subscribe in Bloglines Subscribe in Rojo

Marsha Quinn

Books on Cancer

Keywords and misspellings: prostrate hormane treetments brane braine canser cancar  abc world news tonigh prosetate ransel

Important:  The material on Best Syndication is for informational purposes only and is not a substitute for medical advice or treatment for any medical conditions. You should promptly seek professional medical care if you have any concern about your health, and you should always consult your physician before starting a fitness program.

About   Contact   Site Map

Copyright 2005 Best Syndication                   Last Updated Saturday, July 10, 2010 09:46 PM