Scorpion Venom Used To
Treat Brain Cancer - Radiation and Chemotherapy Can Be Used With TM-601
Breaking Brain Blood Barrier
July 28th 2006
Scientists at the Cedars-Sinai Medical Center’s Maxine Dunitz
Neurosurgical Institute in Los Angeles say that a key ingredient found
in the Giant Yellow Israeli scorpion, TM-601, can transport radioactive
iodine to cancerous glioma cells in the brain. A Phase I study has
been concluded using a synthetic version of the peptide which is found
in this scorpion’s venom.
Glioma is an extremely aggressive and deadly form of brain cancer.
TM-601 binds to glioma cells and has the unusual ability to pass through
the blood-brain barrier that blocks most substances from reaching brain
tissue from the bloodstream.
Dr. Adam N. Mamelak, M.D., a neurosurgeon at Cedars-Sinai and leader of
the Phase I trial, believes TM-601 can be used with other therapies.
The peptide has not affected neighboring tissue or other body organs,
and the clinical trial has been shown to be safe on the 18 patients in