Estrogen and Heart
Disease - Women's Health Initiative - Hormone Replacement Therapy
Potential Risks and Benefits - HRT
April 13th 2006
This new analysis of the Women's Health Initiative Estrogen-Alone trial
is being touted much too strongly by the media, Wyeth, and certain
physicians. They have looked at the data, run with it, and made
conclusions, which is VERY irresponsible at this point in time.
The analysis showed an insignificant "trend" toward heart disease
prevention among women in their 50s, the group of women at lowest risk
for heart disease. There were no trends seen for older women. The
problem with interpreting these results as "beneficial" is that the
number of younger women was too few to draw any conclusions.
What's more, the only significant "trend" regarding estrogen alone and
heart disease was in the first 2 years of the study, which showed a
small INCREASED risk. After that, almost half of the women dropped out
of the study, thus potentially obscuring the results. Like
estrogen-progestin, estrogen alone significantly upped the risk of
stroke and there was also a small risk of blood clots.