potentially promising way to treat Alzheimer's - Lupron
July 22nd 2006
For the last several years, the main drug used to treat Alzheimer's
disease has been Aricept, but its benefit isn't long-lasting, spanning
maybe 18 months to 2 years. Yet surprisingly, a randomized study out
just this week has added another clue to the mystery of this tragic
disease - a drug called leuprolide (brand name Lupron) commonly used to
treat prostate cancer, breast cancer, and endometriosis was found, after
12-48 weeks, to significantly slow the progression of Alzheimer's.
Lupron's mechanism of action is that it blocks LH (luteinizing hormone),
which prompts the pituitary gland to produce gonadotropins, hormones
that stimulate the ovaries and testes to produce the high levels of
estrogen and testosterone necessary for reproduction.
This drug is given as a shot and helps to treat recurrent fibroids or
endometriosis and is used as a way to induce temporary menopause in
early and late stage breast cancer patients; it also shuts down
testosterone production in men with prostate cancer.