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PSA: A controversial but useful test  - Chemotherapy and Radiation Therapies 

PSA: A controversial but useful test  - Chemotherapy and Radiation Therapies

PSA Useful

With the advent of the PSA (Prostate Specific Antigen) blood test two decades ago, the screening for and detecting of prostate cancer in the United States has been revolutionized. 

Introduction

PSA is a protein manufactured in the prostate. There is an association between the PSA level and the likelihood of the man having prostate cancer.

Previously, the only screening test for prostate cancer was a digital rectal exam.  That meant a physician inserted his or her gloved finger into the man’s rectum to determine if he or she felt any lumps or bumps in the prostate gland. By that point, the cancer was relatively far advanced. Fortunately, PSA blood tests can detect a prostate malignancy at a much earlier stage. This is known as a stage shift.  Complete Article


Omega-3 Fatty Acids (Fish) Lowered PSA 77 Percent In Lab Study - Also Lowered Prostate Cancer Tumor Growth by 22 % - Ratio of Omega-6

Omega-3 Fatty Acids (Fish) Lowered PSA 77 Percent In Lab Study - Also Lowered Prostate Cancer Tumor Growth by 22 % - Ratio of Omega-6

Prostate

Scientists from UCLA say that by modifying the typical Western diet to include more fish and less red meat could reduce the prostate cancer growth rate.  The diet requires eating more omega-3 and less omega-6 fatty acids.  This is the first study to show the impact of diet on lowering an inflammatory response known to promote prostate cancer tumor progression.

They believe this finding may lead to a new treatment or aid in the treatment of prostate cancer.  Omega-6 acids come from corn, safflower oils and red meats which are the predominantly the source of polyunsaturated fatty acids in the Western diet.  The omega-3 acids come primarily from cold-water fish like salmon, tuna and sardines.  Complete Article


Breast Cancer - Is Arimidex Better Than Tamoxifen?  Panel Says Arimidex Should Be Treatment of Choice in Some Postmenopausal Women

Breast Cancer - Is Arimidex Better Than Tamoxifen?  Panel Says Arimidex Should Be Treatment of Choice in Some Postmenopausal Women

Cancer Cell

New research shows that AstraZeneca’s new breast cancer drug, Arimidex, is better tolerated than tamoxifen, the current gold standard treatment.   The study found that significantly fewer patients in the Arimidex groups had adverse side effects related to their treatment or that caused them to withdraw from treatment.

Reuters reported that Arimidex also had a significantly better risk-benefit profile, taking into account both the chance that patients would have a recurrence of breast cancer and any side effects.

PRnewswire reports that an international panel of breast cancer specialists confirmed value of aromatase inhibitors (AI) such as Arimdex (anastrozole) as a treatment of hormone receptor-positive early breast cancer in postmenopausal women.  Complete Article


Two Prostate Cancer Breakthroughs May Lead to Better Treatments – Mushroom Extract Aids Chemotherapy and Scientists are Learning Why Cancer Does Not Die

Two Prostate Cancer Breakthroughs May Lead to Better Treatments – Mushroom Extract Aids Chemotherapy and Scientists are Learning Why Cancer Does Not Die

Cancer Cells

Two important findings may help doctors treat cancer.  The first comes from Boston where scientists say that extracts from a mushroom can boost the power of a leading chemotherapy drug used for prostate cancer.  The mushrooms are the same ones used by East Asians for medicine for centuries.

Dr. Chang-Yan Chen said “This species of mushroom has been reported to have some degree of activity in cancer patients. Our aim was to study what effect, if any, extracts of Phellinus linteus have, but we also need to know precisely how it produces these effects.”  Chen is the lead researcher and a doctor at the Boston University School of Medicine in Massachusetts.  Complete Article


New Cancer Drug Approved in Britain - Sutent Expensive But Effective in Fighting Tumors Two Ways - SMART Starve Tumors and Stop Growth

New Cancer Drug Approved in Britain - Sutent Expensive But Effective in Fighting Tumors Two Ways - SMART Starve Tumors and Stop Growth

Sutent

A new line of cancer killing drugs is being offered for sale in Britain today.  The so called “SMART” drug attacks tumors by starving them of nutrients and inhibiting the enzyme that signals cells to multiply.  The two-front approach may be better than the single approach now offered by the extremely successful drug Glivec. 

The UK based news agency, Times Online, says that the news drug, Sutent, is “one of the latest three Glivec-like drugs that are at various stages of development, and which cancer specialists expect to prove useful in treating different kinds of tumours.”  Complete Article


Scorpion Venom Used To Treat Brain Cancer - Radiation and Chemotherapy Can Be Used With TM-601 Breaking Brain Blood Barrier

Scorpion Venom Used To Treat Brain Cancer - Radiation and Chemotherapy Can Be Used With TM-601 Breaking Brain Blood Barrier

Israeli Scorpion

Scientists at the Cedars-Sinai Medical Center’s Maxine Dunitz Neurosurgical Institute in Los Angeles say that a key ingredient found in the Giant Yellow Israeli scorpion, TM-601, can transport radioactive iodine to cancerous glioma cells in the brain.   A Phase I study has been concluded using a synthetic version of the peptide which is found in this scorpion’s venom.

Glioma is an extremely aggressive and deadly form of brain cancer. TM-601 binds to glioma cells and has the unusual ability to pass through the blood-brain barrier that blocks most substances from reaching brain tissue from the bloodstream.  Complete Article


Heat May Be Used To Help Cure Cancer – High Temperatures May Help Radiation and Chemotherapy Kill Tumors – Lance Armstrong Effect

Heat May Be Used To Help Cure Cancer – High Temperatures May Help Radiation and Chemotherapy Kill Tumors – Lance Armstrong Effect

Coffey

Scientists at Johns Hopkins believe that body heat is the reason why people with testicular cancer have a survival rate far better than patients with other advanced cancers.  Cancers that form in the testicles may do so because they are heat sensitive.  Seven-time Tour de France winner Lance Armstrong survived the cancer even after it spread to his lungs and brain.

When the cancer cells spreads to the rest of the body, they may be prone to the increased temperature, making them easier to treat.  The Hopkins researchers say that the temperature boost may have weakened a protein scaffolding within the cancer cell’s nucleus, making the nuclear DNA more vulnerable to chemotherapy and radiation.  Complete Article


Chronic Stress Agitates Ovarian Cancer – Less Stress will Slow Tumor Growth in Mice Study – Beta Blockers Help

Chronic Stress Agitates Ovarian Cancer – Less Stress will Slow Tumor Growth in Mice Study – Beta Blockers Help

Unhealthy Stress

An interesting study on mice has shown that stress can cause tumors to grow more quickly, and the effect can be blocked by a medication commonly prescribed for heart disease.  Dr. Anil Sood said "This study provides a new understanding of how chronic stress and stress factors drive tumor growth."  Sood is an associate professor of gynecologic oncology and cancer biology and director of ovarian cancer research.

When the researchers blocked the stress hormone receptors using the heart disease drug propronolol (a beta-blocker) in the mice, they were able to stop the negative effects of the stress on tumor growth. The researchers chose beta blockers because the same hormone receptors, called beta adrenergic receptors, are found in the heart and normally work to maintain blood flow.  Complete Article


Tamoxifen Pill Not Cost Effective For Most High Risk Breast Cancer Patients - Extends Life For Women With 3% Chance Who Take Drug

Tamoxifen Pill Not Cost Effective For Most High Risk Breast Cancer Patients - Extends Life For Women With 3% Chance Who Take Drug

Tamoxifen Binds To Estrogen Receptor

Researchers in the U.S. and Canada say that most women, even when they are at a very high risk for breast cancer, can not increase their life expectancy by taking the cancer drug tamoxifen.  Tamoxifen was approved by the Food and Drug Administration in 1998 for breast cancer prevention in women who have at least a 1.67-percent chance of developing the disease over the next five years.

The prevention strategy is expensive, according to the researchers.  It costs $1.3 million per year for each life saved.  Joy Melnikow said, "We found that for women at the lower end of the high-risk range for developing breast cancer, there is a very small likelihood that taking tamoxifen will reduce mortality.  This would support revising the current recommended risk threshold for physicians to counsel women about tamoxifen."  Joy is the lead author of the study and professor of family and community medicine at UC Davis School of Medicine and Medical Center.  Complete Article


Leukemia Cancer Drugs May Cause Heart Failure - Gleevec and Other Tyrosine Kinase Inhibitors Toxic and May Cause Problems

Leukemia Cancer Drugs May Cause Heart Failure - Gleevec and Other Tyrosine Kinase Inhibitors Toxic and May Cause Problems

Gleevec

New drugs used to treat leukemia, including Gleevec, may cause serious heart damage, according to U.S. researchers.  The researchers say that people taking the medication should continue to take it, but should also be closely monitored for heart damage.

The researchers from Jefferson Medical College in Philadelphia, Tufts University School of Medicine in Boston, University of Texas released the caution of Sunday, after they found evidence that treatment caused heart failure in 10 patients.  They say that people taking other drugs in the same class, called tyrosine kinase inhibitors, may also be at risk for heart damage.

The drugs have been very successful in treating chronic myelogenous leukemia or CML, in most patients. They have found that 80 to 90 percent of the patients taking the drug were cancer free for at least five years.  The drugs have also been successful in treating a rare form of stomach cancer called gastrointestinal stromal tumors or GIST.  Complete Article


Non-Surgical Lung Cancer Treatment Combination Extends Life - Inoperable Non-Small Cell Tumors Can Be Treated With Heat

Non-Surgical Lung Cancer Treatment Combination Extends Life - Inoperable Small Cell Tumors Can Be Treated With Heat

Thermal Ablation

Researchers have found that 57% of lung cancer patients that undergo thermal ablation survived three years, which is two years longer than the average life expectancy.  The candidates selected for the thermal (heat) treatment were not surgical candidates according to the oncology team which consisted of a pulmonologist, medical oncologist, radiation oncologist and thoracic surgeon.

The treatment involves guiding a needle through the skin into the tumor.  Energy is then applied to the tip of the needle to “cook” and kill the tumor.  The surgeons say the tumors is killed with heat or they can “freeze” it with cold.

The purpose of the study was to assess the clinical outcomes of patients with early-stage non-small cell lung cancer (NSCLC).  The thermal ablation (ablation means removal of unwanted tissue) was combined with radiotherapy.  They found that this combination therapy may result in an improved survival over other treatments alone.  Complete Article


Bladder Cancer – Scientists demonstrates how a protein helps to spread Cancer

Bladder Cancer – Scientists demonstrates how a protein helps to spread Cancer

Courtesy of Sandia National Laboratories

Scientists from the Jefferson Medical College and Jefferson’s Kimmel Cancer Center believe that they have found a protein called proepithelin that helps aid in the spread of bladder cancer.  The study was first reported in the July 15th issue of Cancer Research.

"The fact that proepithelin doesn't appear to strongly promote cell proliferation, but instead promotes migration and invasion – two crucial steps leading to metastasis – suggests that it could be critical for the passage of a cancer from a noninvasive to an invasive phenotype," said Andrea Morrione, Ph.D., research assistant professor of urology at Jefferson Medical College of Thomas Jefferson University and Jefferson's Kimmel Cancer Center in Philadelphia. Complete Article


New Blood Test Screens For Lung Cancer Before X-rays can Detect it - Non-Small Cell Most Common Diagnosed Lung Cancer 

New Blood Test Screens For Lung Cancer Before X-rays can Detect it - Non-Small Cell Most Common Diagnosed Lung Cancer

Lung Cancer

A new blood test can detect non-small cell lung cancer long before it can be detected by an X-ray or computed tomography (CT) scans.  When tested on people being treated for lung cancer, they have been successful in positively identifying 90 percent of cases.  There have been very few false positive cases when samples were taken from people who did not have cancer.

Early detection of non-small cell lung cancer is important because the average five-year survival rate of only 40 per cent.  Early detection may save lives. This is the first new cancer blood screening test since the development of the prostate cancer PSA screening test.  Complete Article


New Data on Raloxifene - Benefits come at a price - Breast Cancer Study Compares Drug to Tamoxifen

New Data on Raloxifene - Benefits come at a price - Breast Cancer Study Compares Drug to Tamoxifen

Tamoxifen and raloxifene

For the past several years, Lilly Pharmaceuticals and the National Cancer Institute have been conducting a head to head trial called STAR, comparing raloxifene (Evista) to Tamoxifen (Nolvadex) to see if one was better than the other at lowering the risk of breast cancer in high risk women.

As expected, both drugs yielded a strong benefit in lowering the risk of invasive breast in the women studied. Raloxifene appeared to be superior to tamoxifen because it provided equal protection against breast cancer while resulting in slightly fewer cases of endometrial cancer, serious blood clots, and cataracts; although, these differences were not large and may have been due to chance. Nevertheless, the results of this trial were sensationalized and made headlines. Complete Article


Common Pain Killer Could Reduce Ovarian Cancer Risk - Tylenol - Acetaminophen - Paracetamol - Cuts Danger By Thirty Percent

Common Pain Killer Could Reduce Ovarian Cancer Risk - Tylenol - Acetaminophen - Paracetamol - Cuts Danger By Thirty Percent

Tylenol

Greek researchers say that regular use of Tylenol (acetaminophen or paracetamol) could reduce the risk of ovarian cancer by almost a third.  The meta-analysis included more than 746,000 women over a six-year period.  They found that 4,405 of the women in the eight major studies – from the USA, UK and Denmark – had ovarian cancer.

They looked at all of the studies that included paracetamol and ovarian cancer from 1966 to 2004.  Dr Stefanos Bonovas said “Meta-analysis involves doing a large amount of research into what has been published, summarising the results and combining them using statistical methods. Analyzing a wide range studies can often throw new light on a problem and raise new research questions.”  Bonovas is the lead researcher from the Greek Ministry of Health.


Cancer Treatments - New Tests Helps to Determine the Effectiveness of Targeted Cancer Drugs

Cancer Treatments - New Tests Helps to Determine the Effectiveness of Targeted Cancer Drugs

Close ups of Cells
image courtesy of Sandia

A new laboratory test that identifies patients who benefit most from targeted cancer drugs was introduced at the annual meeting of the American Society of Clinical Oncology (ASCO) as the test's accuracy is sure to save hundreds of lives per year. This could help solve the problem of knowing which patients can tolerate costly, new treatments and their harmful side-effects. These “smart” drugs do not work for everyone, and a test to determine the efficacy of these drugs in a patient could be the first crucial step in personalizing treatment to the individual.  Cancer Treatments - New Tests Helps to Determine the Effectiveness of Targeted Cancer Drugs


Prostate Health - Beer Ingredient (Hops) May Prevent Prostate Cancer and Enlargement - Xanthohumol Inhibits NF-kappaB Protein in Gland 

Prostate Health - Beer Ingredient (Hops) May Prevent Prostate Cancer and Enlargement - Xanthohumol Inhibits NF-kappaB Protein in Gland

Supplement

Researchers at Oregon State University have found that xanthohumol, a compound found in hops, inhibits NF-kappaB protein in cells along the surface of the prostate gland.  Xanthohumol is a chief ingredient in beer and this finding may lead to a therapy that could prevent both prostate cancer and prostate enlargement.

According to Emily Ho, "We've shown that the addition of xanthohumol in a cell culture blocks the signal of NF-KappaB protein and works to slow down the growth of benign prostatic hyperplasia and malignant prostate cancer cell”.  Ho is assistant professor of nutrition and exercise sciences in OSU's College of Health and Human Sciences and a researcher with OSU’s Linus Pauling Institute.  Prostate Health - Beer Ingredient (Hops) May Prevent Prostate Cancer and Enlargement - Xanthohumol Inhibits NF-kappaB Protein in Gland 


Cancer and Heart Disease are much lower in Asia possibly from drinking Green Tea

Cancer and Heart Disease are much lower in Asia possibly from drinking Green Tea

Green Tea

Scientists call it the ‘Asian Paradox’ because of the lower amounts of cancer and cardiovascular disease in Asians, even though these countries have an abundance of heavy smokers.  Researchers from the Yale School of Medicine theorize that possibly it is related to the high consumption of green tea.  The article was first reported in the Journal of the American College of Surgeons.

"We do not yet have a full explanation for the 'Asian paradox,' which refers to the very low incidence of both heart disease and cancer in Asia, even though consumption of cigarettes is greater than in most other countries," said the lead author, Bauer Sumpio, M.D. who is a professor and Chief of Vascular Surgery in the Department of Surgery. "But we now have some theories."  Cancer and Heart Disease are much lower in Asia possibly from drinking Green Tea


New Brain Tumor Treatment Involves Scorpion Venom – New Narcolepsy Drug used to Ease Fatigue and Depression in Cancer Patients

New Brain Tumor Treatment Involves Scorpion Venom – New Narcolepsy Drug used to Ease Fatigue and Depression in Cancer Patients

Brain Tumor

Researchers say that a drug used to treat narcolepsy, modafinil, (Provigil), has shown promise in relieving symptoms of fatigue in patients with brain tumors.  These improvements have been shown to be “clinically meaningful” in all areas tested including cognitive abilities (21 percent average improvement), mood (35 percent average improvement) and fatigue (average improvement of 47 percent improvement).

The drugs have already been used to help treat depression and fatigue in patients suffering from with multiple sclerosis, Parkinson's disease, stroke, cocaine addiction, HIV infection, and narcolepsy, a condition that causes spontaneous, sometimes unexpected sleep.  New Brain Tumor Treatment Involves Scorpion Venom – New Narcolepsy Drug used to Ease Fatigue and Depression in Cancer Patients 


Yoga Improves Quality of Life For Radiation Therapy Patients - Exercise Program Planned for Breast Cancer Chemotherapy - Study

Yoga Improves Quality of Life For Radiation Therapy Patients - Exercise Program Planned for Breast Cancer Chemotherapy - Study

Yoga

Researchers at the University of Texas M. D. Anderson Cancer Center believe yoga, as part of a treatment plan for cancer patients, can improve the quality of life.  Lorenzo Cohen, Ph.D., associate professor and director of the Integrative Medicine Program at M. D. Anderson presented their findings at the 42nd annual meeting of the American Society of Clinical Oncology.

The research included sixty-one women with breast cancer undergoing radiation.  They were randomized and some took yoga classes twice weekly at or around the time of their radiation therapy appointments.  They created a control group that was “to be offered yoga post-treatment.” The patients ranged from Stage 0 to Stage 3.

The researchers found that after just one week of yoga and radiation, the patients reported increased physical function, as well as general health, compared to the control group.  Also, this group reported better social functioning, significantly lower levels of sleep-related daytime dysfunction, as well as marginally lower levels of fatigue overall.  There was no difference in depression or anxiety levels between the two groups. Yoga Improves Quality of Life For Radiation Therapy Patients - Exercise Program Planned for Breast Cancer Chemotherapy - Study


New Breast Cancer Treatment Tykerb May Compete Against Herceptin - GlazoSmithKline GSK Product Passes Blood Brain Barrier - Low Heart Risk

New Breast Cancer Treatment Tykerb Pill Competes Against Herceptin - GlazoSmithKline GSK Product Passes Blood Brain Barrier - Low Heart Risk

Tykerb Mechanism

Tykerb, a new drug produced by GlazoSmithKline (GSK), is showing promise in treating breast cancer where Herceptin fails to respond.  Tykerb is a pill that can be taken orally, compared to other chemotherapy drugs which must be injection.  It is also a smaller molecule and can pass through the blood brain barrier to attack breast cancer that has spread to the brain.

According to the researchers, 62 percent of women with HER2 IBC cancers had a clinical response to Tykerb. The women in the study had aggressive HER2 type of breast cancer, and had already taken other drugs until they failed to respond to treatment.  These other drugs included Roche Holding AG's and Genentech Inc's top-selling Herceptin.  New Breast Cancer Treatment Tykerb Pill Competes Against Herceptin - GlazoSmithKline GSK Product Passes Blood Brain Barrier - Low Heart Risk


Herceptin Improved Treatment For Both Early Stage And Advanced HER2 Positive Breast Cancer - Also Combined With Chemotherapy

Herceptin Improved Treatment For Both Early Stage And Advanced HER2 Positive Breast Cancer - Also Combined With Chemotherapy

Health

Patients with breast cancer that overexpress a protein known as the human epidermal growth factor receptor-2 (HER2), can improve their chance of survival by combining Herceptin® (trastuzumab) and Arimidex® (anastrozole), compared to Arimidex alone.  Currently Herceptin is approved for as initial therapy in addition to the chemotherapy agent Taxol® (paclitaxel) in advanced, HER2-positive breast cancer.  Herceptin is also approved as a single agent in patients where breast cancer has progressed following a prior therapy.

In about 30% of the breast cancers, the HER2 protein is overexpressed.  These cases typically have a worse prognosis than women with HER2-negative breast cancer.  According to Roche, the maker of Herceptin, the targeted agent Herceptin binds to HER2 receptors and prevents or reduces replication of cancer cells that overexpress HER2.  Herceptin Improved Treatment For Both Early Stage And Advanced HER2 Positive Breast Cancer - Also Combined With Chemotherapy


A new wesbite launched by Wyeth called knowmenopause.com

A new wesbite launched by Wyeth called knowmenopause.com

Health

Several years ago, Wyeth developed a wesbite called menopausehealth.com as part of an "educational" campaign for women entitled VITALITY: HEALTH AND WELLNESS FOR MIDLIFE AND BEYOND. It piggy-backed off of the ubiquitous TV and print ads featuring Lauren Hutton touting hormone replacement as a longterm therapy for feeling and looking good and for maintaining health. The wesbite didn't outright state that estrogen prevented all of these diseases, just that the evidence was mounting that estrogen LOSS caused all of them and that the small increased risk of breast cancer associated with HRT (which paid breast specialist Michele Blackwood said might not even exist) would, at worst, be mitigated by the reductions in heart disease, colon cancer, Alzheimer's, bone loss, tooth loss, you name it!  A new wesbite launched by Wyeth called knowmenopause.com


Lung Cancer – Tumor growth increases with loss of a Protein

Lung Cancer – Tumor growth increases with loss of a Protein

Lungs

Zafira Castaño who is a researcher and Doctor in Biochemistry from the University of Navarra in Spain, discovered a connection between lower levels of αCP4 protein in early stages of lung cancer help tumor growth.

Castaño noticed that these αCP4 protein cells are found on tissue cells within a healthy lung.  However in a lung that was in first phase of cancer there was a loss of this protein.  The αCP4 protein was also lacking in 67% of the tumors as well.

To confirm the findings Castaño took samples of various cellular lines from different kinds of lung tumors.  She then introduced a series of the αCP4 protein to the tumor tissues to see what would result.  Some of the tumors responded to the introduction of the protein.  Tumor proliferations were reduced with malignant tumors of large cells she noticed that their ability to grow was reduced.   Lung Cancer – Tumor growth increases with loss of a Protein


The Mouse That Cured Cancer – White Blood Cells from Resistant Mice Also Prevented All Forms – One Injection Lifetime Cure - Next Humans

The Mouse That Cured Cancer – White Blood Cells from Resistant Mice Also Prevented All Forms – One Injection Lifetime Cure - Next Humans

Neutrophils

In 1999 an unexpected event occurred when scientists injected cancer cells into a group of mice; one mouse did not get the cancer.  Even after repeated injections the mouse did not get any type of cancer.  It appears the white blood cells from the mouse surrounded tumors and proceeded to kill them, even in advanced forms of cancer.

Not only did the white blood cells kill the cancer in the original mouse, they were able to kill advanced forms of cancer in ordinary mice after injecting them with the white blood cells.  According to Zheng Cui, M.D, “Even highly aggressive forms of malignancy with extremely large tumors were eradicated."  Cui and his colleagues reported this in the on-line edition of Proceedings of the National Academy of Sciences. The Mouse That Cured Cancer – White Blood Cells from Resistant Mice Also Prevented All Forms – One Injection Lifetime Cure - Next Humans


Air Fresheners and Cleaning Chemicals could have Health Risks

Air Fresheners and Cleaning Chemicals could have Health Risks

Mop Bucket

According to a research study from the University of California, Berkeley and Lawrence Berkeley National Laboratory air fresheners and cleaning chemicals used indoors could be bad for your health.

When used indoors in a small space, commonly used household cleaners and air fresheners emit toxic pollutants, which are sometimes at dangerous levels and could lead to health problems.

The pollutants along with the secondary pollutants that are formed when mixed with the ozone might exceed regulatory guidelines if used in a small room while cleaning a large surface area on a regular basis.  Chronic exposure increases the toxic exposure and the health risks.

The study researched the amounts of primary and secondary toxic compounds created in with a variety of different cleaning and air freshener chemicals in an indoor setting, to determine any potential hazards of using these products.  Air Fresheners and Cleaning Chemicals could have Health Risks


Enlarged Prostate – Botox may help relieve Symptoms of BPH

Enlarged Prostate – Botox may help relieve Symptoms of BPH

Botox Injection

Botox also known as botulinum toxin A may have a new treatment to help relieve the symptoms of benign prostatic hyperplasia (BPH) also known as enlarged prostate.  Botox which is known to be used in cosmetic procedures to remove wrinkles also helps in treating other conditions.  This new study using the toxin for enlarged prostate may add to Botox’s list of treatments. 

Researchers from the Chang Gung University Medical College, Taiwan and the University of Pittsburgh School of Medicine completed a study that injected Botox into the men that have an enlarged prostate gland.  They will present their results at the American Urological Association (AUA) and will be published in the AUA proceedings (abstract 1436).  Enlarged Prostate – Botox may help relieve Symptoms of BPH


Benzene Found in 5 Soft Drinks - FDA Tested 100 Sodas - Exceeds EPA Levels of Cancer Causing Ingredients - List of Beverages

Benzene Found in 5 Soft Drinks - FDA Tested 100 Sodas - Exceeds EPA Levels of Cancer Causing Ingredients - List of Beverages

Health

The Food and Drug Administration (FDA) found benzene, a known carcinogen for humans, in several soft drinks.  The FDA says the levels are higher than 5 parts per billion, which is the limit the Environmental Protection Agency (EPA) allows for drinking water. 

The FDA said that “although one sample from a production lot may contain elevated benzene levels, it does not mean that all the products from that lot will have elevated levels, or that all lots of a given product will contain elevated levels."

The companies involved have been notified and have reformulated their drinks or plan to comply with EPA standards. According to Forbes reporter, Andrew Bridges, benzene is linked to leukemia and can form in soft drinks containing two ingredients: Vitamin C, also called ascorbic acid, and either of the two preservatives: sodium benzoate and potassium benzoate.  Benzene Found in 5 Soft Drinks - FDA Tested 100 Sodas - Exceeds EPA Levels of Cancer Causing Ingredients - List of Beverages


Cancer – Killing cancer cells with a modified Vitamin E Succinate

Cancer – Killing cancer cells with a modified Vitamin E Succinate

Vitamin E supplement

Researchers from The Ohio State University Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) found that a derived form of vitamin E can cause cancer cells to die.  The study was first published in the April 28th issue of the Journal of Biological Chemistry.

Vitamin E succinate also known as alpha tocopheryl succinate which is available in supplement form is often taken due to the antioxidant benefits.  There has been some previous research that has shown a slight ability to kill cancer cells when taking this supplement.  Vitamin E succinate has been considered a chemopreventive agent.

The method the cancer cells are killed is through a natural process called apoptosis which is a programmed cell death.  The researchers wanted to further understand why the vitamin E succinate was capable of killing cancer cells.  Cancer – Killing cancer cells with a modified Vitamin E Succinate


Gardisil HPV Vaccine Approved By FDA Panel - May Prevent Cervical Cancer - Approval Could Prevent Most Common Sexual Virus

Gardisil HPV Vaccine Approved By FDA Panel - May Prevent Cervical Cancer - Approval Could Prevent Most Common Sexual Virus

HPV Virus

A U.S. Food and Drug Administration advisory panel recommended approval (13 to 0 vote) of the first vaccine to fight cancer.  The vaccine, Gardisil (quadrivalent human papillomavirus types 6, 11, 16, 18, recombinant vaccine), is a vaccine that can be used against the human papilloma virus (HPV) which has been linked to cervical cancer.  The FDA is not required to follow the advice of its panels, but they usually do.  A decision on approval by the FDA is expected by June 8.

Gardisil, manufactured by Merck, is a vaccine that is most effective in women before they become sexually active.  It is hoped the vaccine will help prevent hundreds of thousands of women from dying worldwide of cervical cancer.  According to the University of Alabama at Birmingham, it is estimated that 450,000 women are diagnosed with cervical cancer annually and 200,000 women die each year from the disease.  Other sources say the number of deaths might be as high as 300,000 per year.  In the U.S. approximately 12,000 women are diagnosed with cervical cancer, resulting in 4,500 deaths each year.  Gardisil HPV Vaccine Approved By FDA Panel - May Prevent Cervical Cancer - Approval Could Prevent Most Common Sexual Virus


Addiction to Tanning Physiological Not Just Mental - Tanners Becoming Younger - Good Morning America Segment Highlights Dangers

Addiction to Tanning Physiological Not Just Mental - Tanners Becoming Younger - Good Morning America Segment Highlights Dangers

Health

Researchers have discovered that tanning can be addictive, just like drugs and alcohol.  Last year scientists compared frequent tanners and found that tanners that were given the drug naltrexone had withdraw symptoms, but those who got the drug did.  Naltexone blocks a narcotic-like substance produced in the skin during tanning. 

According to Daniel DeNoon of WebMD, the researchers found that a 50-milligram dose of naltrexone could cause physiological withdrawal: nausea, dizziness, and shaking.  This prompted the researchers to stop the study early.  Mandeep Kaur, MD said "In the beginning, we gave standard 50-milligram doses of naltrexone to frequent tanners.  All of them developed symptoms consistent with <withdraw>. So we had to stop that study."  Kaur is a dermatologist at Wake Forest University Baptist Medical Center.  Addiction to Tanning Physiological Not Just Mental - Tanners Becoming Younger - Good Morning America Segment Highlights Dangers


Exercise Prevents Cancer By Promoting Cell Death - Both Skin and Bowel Cancer Studies Show Voluntary Workouts Reduce Risk

Exercise Prevents Cancer By Promoting Cell Death - Both Skin and Bowel Cancer Studies Show Voluntary Workouts Reduce Risk

Skin cancer

Two studies highlight the benefits of exercise, including lower risks of skin cancer and bowel cancer.  In the first study, published in the journal Carcinogenesis, exposed female mice to ultraviolet B light (UVB).  The researchers found that the mice that had 24-hour access to running wheels took longer to develop skin tumors and had fewer of them.  The tumors were also smaller in the mice that were exercising. 

Scientists believe that programmed cell death, called apoptosis, can be triggered by exercise.  The problem with cancer cells is that they do not die like normal cells. Dr. Allan Conney said “Preliminary indications from follow-up work in the laboratory suggest that voluntary exercise enhances UVB-induced apoptosis in the skin, and that it also enhances apoptosis in UVB-induced tumors. So, although UVB is triggering the development of tumors, exercise is counteracting the effect by stimulating the death of the developing cancer cells.”  Dr. Conney is Garbe professor of Cancer and Leukemia Research.  Exercise Prevents Cancer By Promoting Cell Death - Both Skin and Bowel Cancer Studies Show Voluntary Workouts Reduce Risk


Prostate Cancer – Consuming excess Milk and Meat may Increase Risk

Prostate Cancer – Consuming excess Milk and Meat may Increas

Glass of Milk

According to a report on the Physicians Committee for Responsible Medicine website, consuming too much dairy and meat may increase a man’s risk for developing prostate cancer.

They have assembled a collection of studies that show possible clues as to why the dairy and meat may have contributed to the increased risk for prostate cancer in men. 

They believe that the risk is higher is due to the saturated fat levels among other factors.  In the American diet we consume way too much saturated fat in relationship to the unsaturated fat.  This dietary imbalance could be a large contributing factor.  Prostate Cancer – Consuming excess Milk and Meat may Increase Risk


Nurses' Health Study links Estrogen use to Breast Cancer

Nurses' Health Study links Estrogen use to Breast Cancer

HRT Effects

The Nurses' Health Study (NHS) is an ongoing longterm cohort study examining the health of nurses compared to the general population. It is an observational study that, while interesting, falls short of the precision of a randomized clinical trial. The study, nevertheless, is important because it has prompted further research.

In the NHS, HRT use (either estrogen alone or estrogen/progestin) has been examined among these women for its potential effects on disease outcomes. As many know, it found lower rates of heart disease among hormone users and higher rates of breast cancer.

While these findings are informative, they haven't been paralleled (COMPLETELY) in clinical trials. For example, NHS found that women who initiated HRT at ANY AGE reduced their risk of heart disease. Nurses' Health Study links Estrogen use to Breast Cancer


New Zealand Considers Graphic Images on Cigarette Packs Including Pictures of Throat Cancer Rotting Teeth and Gums

New Zealand Considers Graphic Images on Cigarette Packs Including Pictures of Throat Cancer Rotting Teeth and Gums

Health

New Zealand is considering putting strong pictures on cigarette packs sold in their country in an effort to curb smoking.  The Ministry of Health is releasing a proposal that would include pictures of “harsh evidence of the harms associated with smoking, including photos of smokers with throat cancer, rotting teeth and gums and gangrenous feet.”  This is according to Auckland Radio Station NewsTalk ZB 89.

The Ministry is looking for feedback before they begin the health warnings.  There are other countries that have already included graphic warnings on their cigarette packs.  These countries include Canada, Australia, Brazil and Thailand. 

Many countries already provide written warnings on their cigarette packs.  Radio New Zealand reports that the Ministry believes graphic warnings would be more effective than just written words. New Zealand Considers Graphic Images on Cigarette Packs Including Pictures of Throat Cancer Rotting Teeth and Gums


Estrogen Hormone Replacement Therapy HRT Safer For Short Term - Significant Breast Cancer Risk in Long Term Users - 20 Years

Estrogen Hormone Replacement Therapy HRT Safer For Short Term - Significant Breast Cancer Risk in Long Term Users - 20 Years

Estrogen

An article in this issue of Archives of Internal Medicine suggests that the long-term use of oestrogen-only hormone replacement therapy (HRT) does increase the risk of breast cancer. The authors say that “short-term unopposed estrogen use does not seem to increase breast cancer risk”.

The researchers used data from the Nurses’ Health Study.  They observed 11,508 postmenopausal women who had a hysterectomy and reported information on estrogen use at baseline (1980).  The study population expanded every two years until a total of 28,835 women were included in the final follow-up period between the years 2000 and 2002.

The women were assessed using self-reported data on biennial questionnaires.  The results seem to conflict with a Stanford University study just last month that found no evidence of any increased risk in women who used the therapy for up to seven years.  But does it conflict?  Estrogen Hormone Replacement Therapy HRT Safer For Short Term - Significant Breast Cancer Risk in Long Term Users - 20 Years


M. D. Anderson Cancer Center Makes Advances in Treatment of Gloioblastoma Brain Tumors Including Drugs and Proton Therapy

M. D. Anderson Cancer Center Makes Advances in Treatment of Gloioblastoma Brain Tumors Including Drugs and Proton Therapy

Proton Therapy Center

There are some promising new treatments for glioblastoma, the most common and deadly of brain tumors, according to the M.D. Anderson Cancer Center in Texas.  The researchers at the University of Texas M. D. Anderson Cancer Center believe they are poised on the brink of a new era, and that glioblastoma is finally giving up some secrets.

The report says that the researchers have found a new chemotherapy drug that works best in patients who have no expression of a specific genetic alteration.  The researchers are investigating 20,000 genes and proteins that may play a role in brain tumor development. M. D. Anderson Cancer Center Makes Advances in Treatment of Gloioblastoma Brain Tumors Including Drugs and Proton Therapy


Colon Cancer – DNA gets ‘switched off’ and allows Tumor Growth

Colon Cancer – DNA gets ‘switched off’ and allows Tumor Growth

DNA

Researchers from Sydney’s Garvan Institute along with a collaborative effort with Spanish scientists have led to new understanding how cancer cells take over and tumors grow.  They discovered in the process of colon cancer that large areas of DNA are turned off allowing for the growth of tumors.  The study was first reported in the Nature Genetics, April 23rd edition.

The lead researcher Sue Clark, who is an Associate Professor at the Garvan Institute said, "These large regions – referred to as suburbs – contain genes that normally function to prevent the development of tumours."  Colon Cancer – DNA gets ‘switched off’ and allows Tumor Growth


FDA Claims Marijuana Too Dangerous For Medical Purposes - This is Counter to Previous Government Findings - Studies Show Benefits for Nausea and Pain

FDA Claims Marijuana Too Dangerous For Medical Purposes - This is Counter to Previous Government Findings - Studies Show Benefits for Nausea and Pain

Marijuana

The Food and Drug Administration (FDA) claims that marijuana is too dangerous to be used as a medicine.  According to the FDA, marijuana “met the three criteria for placement in Schedule I under 21 U.S.C. 812(b)(1) (e.g., marijuana has a high potential for abuse, has no currently accepted medical use in treatment in the United States, and has a lack of accepted safety for use under medical supervision).”

This new FDA finding runs counter to the previous independent report that shows the medical benefits of marijuana.  In 1997 the White House Office of National Drug Control Policy (ONDCP) asked the Institute of Medicine to conduct a review of the scientific evidence to assess the potential health benefits and risks of marijuana and its constituent cannabinoids.

The Institute points out that marijuana users can develop a dependence on the drug.  The FDA currently approves other drugs that cause dependency.  But the Institute went on to report that there are some medical uses for marijuana.  FDA Claims Marijuana Too Dangerous For Medical Purposes - This is Counter to Previous Government Findings - Studies Show Benefits for Nausea and Pain


Breast Cancer Risk Not Increased With Implants - Swedish Study Found This Silicone Implants - Cosmetic Surgery Does Not Cause Cancer

Breast Cancer Risk Not Increased With Implants - Swedish Study Found This Silicone Implants - Cosmetic Surgery Does Not Cause Cancer

Silicone Implant

A new study found that breast implants do not cause breast cancer.  Researchers from the Vanderbilt-Ingram Cancer Center say this is the longest follow-up study to date of cancer incidence among women with silicone breast implants.  This study shows that having implants does not put women at an increased risk for cancer, but actually shows to be associated with a decreased breast cancer risk.

The researchers studied 3,486 Swedish women with cosmetic breast implants implanted for the first time from 1965 to 1993.  The Swedes have the best cancer registries in the world, going back almost 50 years, according to Joseph McLaughlin, Ph.D.  McLaughlin is a cancer epidemiologist with the Vanderbilt-Ingram Cancer Center and the International Epidemiology Institute.  McLaughlin worked with colleagues at the Karolinska Institute in Stockholm, Sweden to determine breast cancer risk.  Breast Cancer Risk Not Increased With Implants - Swedish Study Found This Silicone Implants - Cosmetic Surgery Does Not Cause Cancer


Breast Cancer Risk Cut in Half with Evista - STAR Study Indicates Protection Offered By Raloxifene HCL - No Reduction in Heart Death

Breast Cancer Risk Cut in Half with Evista - STAR Study Indicates Protection Offered By Raloxifene HCL - No Reduction in Heart Death

Evista

Researchers have determined that Evista (raloxifene HCL) can reduce the risk of developing breast cancer by about half.  The Study of Tamoxifen and Raloxifene (STAR) found that Evista, an osteoporosis drug, works as well as the older drug used to treat cancer, tamoxifen, in reducing the risk of breast cancer in high-risk women, but with fewer dangerous side effects.

Evista is marketed by Eli Lilly for the treatment of osteoporosis in postmenopausal women.  The new breast cancer protection findings were announced by the National Surgical Adjuvant Breast and Bowel Project (NSABP).  Steven Paul, M.D., executive vice president of science and technology, Lilly said “NSABP's STAR study represents an important milestone in cancer research."

Eli Lilly and company, the maker of the drug, announced they will likely petition the Food and Drug Administration (FDA) to allow the drug to be prescribed for patients at high risk of developing breast cancer.  Currently, raloxifene is not approved by the FDA for preventing or reducing the risk of cardiovascular disease or invasive breast cancer.  Breast Cancer Risk Cut in Half with Evista - STAR Study Indicates Protection Offered By Raloxifene HCL - No Reduction in Heart Death


Link Between Prostate Cancer and High Cholesterol - Testosterone and Goldstones Are Both Synthesized from Cholesterol - Italian Research

Link Between Prostate Cancer and High Cholesterol - Testosterone and Goldstones Are Both Synthesized from Cholesterol - Italian Research

Cholesterol Test

Italian researchers say they have found a link between high cholesterol and prostate cancer.  According to the co-author, Dr. Cristina Bosetti, “Androgens – hormones that have a role in prostate tissue and cancer – are synthesised from cholesterol, suggesting a possible biological relationship between high cholesterol and prostate cancer. Gallstones are related to high cholesterol levels as well and are often composed of cholesterol. So, the direct relationship we found between gallstones and prostate cancer, while it was not statistically significant, suggests a similar biological mechanism may explain the link."  Androgens are male sex hormones, like testosterone. 

Although an association between prostate cancer and high cholesterol has been suggested, this study published in the on-line (Wednesday 12 April) in Annals of Oncology, shows a statistically significant direct relationship between the two.  The researchers relied on their participant's self-reporting of medical conditions.  Link Between Prostate Cancer and High Cholesterol - Testosterone and Goldstones Are Both Synthesized from Cholesterol - Italian Research


Hormone Replacement Therapy May Not Increase Breast Cancer Risk - Estrogen Pills (HRT) can Cause Strokes Blood Clots and Dementia

Hormone Replacement Therapy May Not Increase Breast Cancer Risk - Estrogen Pills (HRT) can Cause Strokes Blood Clots and Dementia

Estrogen

The latest data from Women's Health Initiative (WHI) shows that estrogen alone used for 7 years or less in women with hysterectomy does not increase the risk (or perhaps the detection) of breast cancer in general. A non-significant trend towards fewer cases was noted. Obviously if this were the only finding it would be good news but it's lot more confusing than that. Nevertheless, Wyeth, the maker of Premarin, and a few of its designated, well paid mouthpieces are at it again, saying estrogen is protective.

They've got Hugh Taylor from Yale and Wolf Utian of the North American Menopause Society (a veteran HRT proponent) touting these results with great enthusiasm. Highly irresponsible, for several reasons!! - The "reduced risk" was not significant and the cancers of the women on estrogen were larger and involved lymph nodes. Plus the women on estrogen required additional testing or biopsies, and there appeared to be an INCREASED RISK of breast cancer for those women with risk factors.  Hormone Replacement Therapy May Not Increase Breast Cancer Risk - Estrogen Pills (HRT) can Cause Strokes Blood Clots and Dementia


Nano-Technology Used to Fight Cancer - Researchers Use Nano-Particles That Are Able to Kill Tumor Cells - Nanoparticles Target Tumors

Nano-Technology Used to Fight Cancer - Researchers Use Nano-Particles That Are Able to Kill Tumor Cells - Nanoparticles Target Tumors

Polymersome

Researchers at the University of Pennsylvania have effectively used nano-particles to kill breast cancer tumors along with chemotherapeutics. These tiny particles contain a hollow shell that can be filled with chemicals used to kill tumors.  The two potent chemicals used were paclitaxel, the leading cancer drug known by brand names such as Taxol, and doxorubicin.  This technique allowed the particles to move directly to the tumors implanted in mice.

This technique of drug-delivery is better than previous methods.  Dennis Discher, professor in Penn's School of Engineering and Applied Science and a member of Penn's newly established Institute for Translational Medicine and Therapeutics said, “The system provides a number of advantages over other Trojan horse-style drug delivery system, and should prove a useful tool in fighting a number of diseases.  Here we show that drug-delivering polymersomes will break down in the acidic environment of the cancer cells, allowing us to target these drugs within tumor cells."  Nano-Technology Used to Fight Cancer - Researchers Use Nano-Particles That Are Able to Kill Tumor Cells - Nanoparticles Target Tumors


Prostate Cancer – Eating Cruciferous Vegetables can help slow Tumor Growth

Prostate Cancer – Eating Cruciferous Vegetables can help slow Tumor Growth

Cauliflower

Eating broccoli, cabbage, cauliflower and other cruciferous vegetables have shown to stop human prostate cancer cells from growing in mice.  The study is being presented today at the American Association for Cancer Research annual meeting in Washington, D.C.

"The contribution of diet and nutrition to cancer risk, prevention and treatment have been a major focus of research in recent years because certain nutrients in vegetables and dietary agents appear to protect the body against diseases such as cancer," said Shivendra Singh, Ph.D. who is the lead research and is also a professor of pharmacology and urology at the University of Pittsburgh School of Medicine. "From epidemiologic data, we know that increased consumption of vegetables reduces the risk for certain types of cancer, but now we are beginning to understand the mechanisms by which certain edible vegetables like broccoli help our bodies fight cancer and other diseases."  Prostate Cancer – Eating Cruciferous Vegetables can help slow Tumor Growth


Cancer Tumor Growth may be increased by Drinking 2 – 4 Alcoholic Drinks Daily

Cancer Tumor Growth may be increased by Drinking 2 – 4 Alcoholic Drinks Daily

Glass of Wine

A recent study from the University of Mississippi found that alcohol consumption can help in the growth of tumors by stimulating vascular endothelial growth factor (VEGF).

VEGF is a necessary substance that the body needs, but when there is too much it can be harmful.  The researchers in this study used mice to investigate how alcohol consumption in mammals would help in the growth of tumors.  Future research may help in finding ways to slow down the production of VEGF.

The research study was first presented by Wei Tan, Megan Shparago, Amelia P. Bailey and Jian-Wei Gu of the University of Mississippi Medical Center at the Experimental Biology Conference 2006 which was from April 1-5 in San Francisco.  Cancer Tumor Growth may be increased by Drinking 2 – 4 Alcoholic Drinks Daily


Brachytherapy: An effective form of radiation therapy

Brachytherapy: An effective form of radiation therapy

Author's Book

Brachytherpy (pronounced bray-kee-ther-uh-pee) is a Greek term; "brachy" means short distance and "therapy" means treatment.  It is the form of radiation therapy that places radioactive materials, or sources, in or just next to a tumor or body site at risk for harboring tumor cells.  This is in contrast to external beam radiation therapy, which is delivered via a linear accelerator at a distance from the tumor, outside the person’s body.

During brachytherapy, the radioactive source or sources are left in place temporarily or permanently, depending on the type of cancer.  To position the source or sources accurately, special small tubes called catheters or applicators are used.  Also, depending on the area being treated, people may undergo several treatments over a number of days or weeks.

There are two main categories of brachytherapy: intracavitary treatment and interstitial treatment.  With the former, the radioactive source or sources are inserted into a space near the tumor’s location, such as the cervix, the vagina, the esophagus, or the windpipe.  With the latter form of brachytherapy, the radioactive material is implanted directly into the tissues, such as the prostate.  In fact, a prostate seed implant is an example of an interstitial implant.  Brachytherapy: An effective form of radiation therapy


Add Celebrex to the List of Drugs that Help Prevent Colon Cancer – Aspirin Pain Relievers May Lower Risk of Colorectal Pre-Cancerous Polyps

Add Celebrex to the List of Drugs that Help Prevent Colon Cancer – Aspirin Pain Relievers May Lower Risk of Colorectal Pre-Cancerous Polyps

Tubular adenoma

It appears that Celebrex (celecoxib) may help inhibit the formation of pre-cancerous sporadic adenomatous polyps (adenomas) that can lead to colon cancer.  One of the two studies, one funded in part by Celebrex maker Pfizer, and the National Cancer Institute, found that “sustained, higher doses of Celebrex for almost three years reduced pre-cancerous polyps (adenomas) with the greatest benefit for those at highest risk of polyp recurrence.”

Both studies enrolled patients that have already had precancerous colon polyps removed.  Most participants were about 60 years old at the start of trial and most had cardiovascular risk factors such as high blood pressure, diabetes, angina, previous heart attacks, strokes or were smokers.  

In the first study, Prevention of Sporadic Adenomatous Polyps (PreSAP), about 34% of the patients on 400mg Celebrex developed pre-cancerous polyps over the three-year study.  Of the placebo group, 42% developed the polyps.  Add Celebrex to the List of Drugs that Help Prevent Colon Cancer – Aspirin Pain Relievers May Lower Risk of Colorectal Pre-Cancerous Polyps


Heavy Cell Phone Use Linked To Brain Cancer – Mobile Phones May Cause Malignant Brain Tumors on Same Side of Head – Swedish Study

Heavy Cell Phone Use Linked To Brain Cancer – Mobile Phones May Cause Malignant Brain Tumors on Same Side of Head – Swedish Study

Mobile Phone Use

Swedish researchers believe that heavy users of cells phones have an increased risk of malignant brain tumors.  This contradicts earlier studies.  Research last year, conducted by the Dutch health Council, found no evidence that radiation from mobile phones and TV towers was harmful.  Also, a four year British study found no link between regular, long-term use of cell phones and the most common type of tumor.

This new Swedish study released on Friday contradicted these earlier conclusions.  The researchers at the Swedish National Institute for Working Life looked at the mobile phone use of 2,200 cancer patients and compared this to an equal number of healthy control cases.

Of the cancer patients, 905 had a malignant brain tumor and about a tenth of these patients were heavy mobile phone users.  "Of these 905 cases, 85 were so-called high users of mobile phones, that is they began early to use mobile and/or wireless telephones and used them a lot," according to the researchers.  Heavy Cell Phone Use Linked To Brain Cancer – Mobile Phones May Cause Malignant Brain Tumors on Same Side of Head – Swedish Study


Weight Training Twice as Effective Compared to Aerobic Exercise In Improving Quality of Life in Breast Cancer Survivors After Surgery

Weight Training Twice as Effective Compared to Aerobic Exercise In Improving Quality of Life in Breast Cancer Survivors After Surgery

Strength Training

Researchers believe that weight training significantly improves the quality of life in women recently treated for breast cancer.  Minnesota doctors found that six months of twice weekly exercise that improved strength and body composition was enough to result in improvements in the overall physical and emotional condition of the patients.

It is not unusual for newly diagnosed and treated breast cancer patients to suffer from multitude quality of life limiting complaints, including insomnia, weight gain, chronic fatigue, depression, and anxiety.  Although treatments for breast cancer have progressed rapidly, treatment for these secondary complaints has only recently been compared. 

There are several physical options available for the management of these secondary issues involving breast cancer survivors.  The researchers compared aerobic and weight training and found weight training produced better results.  Weight Training Twice as Effective Compared to Aerobic Exercise In Improving Quality of Life in Breast Cancer Survivors After Surgery


Treatment Options For Prostate Cancer Investigated - Is Invasive Treatment Better than Watching and Waiting Approach - Symptoms

Treatment Options For Prostate Cancer Investigated - Is Invasive Treatment Better than Watching and Waiting Approach - Symptoms

Prostate

A new study is underway to determine if low-risk prostate cancer patients do better or as well using the watchful waiting approach compared to those that have invasive surgery. In this study 200 of the 650 patients needed have already enrolled.  These men have been diagnosed with low-risk prostate cancer at M. D. Anderson and are on active surveillance for their disease, having changes monitored through regular Prostate Specific Antigen (PSA) tests, biopsies and check-ups.

Now that men are routinely tested for PSA blood test beginning in their 40’s, thousands of men have had their prostate cancer detected at such an early stage that managing low-risk disease through surveillance may outweigh the risks and possible side effects of treatments.  This is what doctors at The University of Texas M. D. Anderson Cancer Center hope to determine with their new study.

Jeri Kim, M.D said "With the advent of the PSA test, we see prostate cancer detected much earlier but there is no evidence that early detection means longer survival. Because of the sensitivity of the test, clinically insignificant tumors sometimes are over-diagnosed and patients may, as a consequence, be over-treated with radiation and surgery.”  Kim is the principal investigator of the study and assistant professor in the Department of Genitourinary Medical Oncology at M. D. Anderson.  Treatment Options For Prostate Cancer Investigated - Is Invasive Treatment Better than Watching and Waiting Approach - Symptoms


Emphysema - Smokers can get Healthier Lungs by eating more Fruits and Vegetable containing Beta Carotene and Vitamin E

Emphysema - Smokers can get Healthier Lungs by eating more Fruits and Vegetable containing Beta Carotene and Vitamin E

Carrots are high in beta carotene

Researchers measured beta carotene levels in blood samples of men and women and found that those that had higher levels also had better lung function.  If you are a smoker, you probably think about lung cancer and emphysema and know that the best thing to do is quit smoking altogether.  In the mean time you might want to consider eating foods rich in beta carotene as well.

This study suggests that by eating fruits and vegetables that are high in beta-carotene, like carrots and sweet potatoes can help your lungs breathe better over time.  The researchers also measured for vitamin E and found this to be helpful too.

According to a recent Ivanhoe publication, there were approximately 1,200 men and women between the ages of 20 - 44 that participated.  In 1992, the participants had blood test to measure their level of beta carotene, vitamin A, and vitamin E.  They also did a lung function test when the blood sample was taken.  The lung function test measures the volume of air exhaled after one second of taking a deep breath.  The test is called FEV1 and is used to determine a person’s lung function.  Emphysema - Smokers can get Healthier Lungs by eating more Fruits and Vegetable containing Beta Carotene and Vitamin E


Avastin in Combination With Chemotherapy Stabilizes Breast Cancer Twice as Long as Chemo Alone - Advanced Stages Tested - Early Stages Next

Avastin in Combination With Chemotherapy Stabilizes Breast Cancer Twice as Long as Chemo Alone - Advanced Stages Tested - Early Stages Next

Avastin

Researchers say that combining the drug Avastin with standard chemotherapy can keep breast cancer under control for a longer period of time in patients with the advanced disease.  Now the researchers want to find out if the combination therapy will help patients when the disease has not metastasized. 

Doctors combined the drug with the chemotherapy treatment Taxol in 722 patients.  They found that the cancer was stable for 11.4 months in women who received the drug combo compared to 6.11 months in patients that were only given Taxol.  This combined therapy kept the cancer under control for almost twice as long as relying on the chemotherapy alone. 

It is common for doctors to prescribe multiple drugs to treat an illness.  In the case of Avastin and Taxol, the chemotherapy drug attacks the tumors directly and Avastin interferes with the formation of blood vessels, effectively starving the tumors for nutrients. Avastin in Combination With Chemotherapy Stabilizes Breast Cancer Twice as Long as Chemo Alone - Advanced Stages Tested - Early Stages Next


Omega-3 Fatty Acids Prevent Spread of Prostate Cancer - Fish Oil Better Than Vegetable Sources - Omega-6 Used as Energy By Cancer Cells and Tumors

Omega-3 Fatty Acids Prevent Spread of Prostate Cancer - Fish Oil Better Than Vegetable Sources - Omega-6 Used as Energy By Cancer Cells and Tumors

Fish Better Source for Omega

Scientists from the Paterson Institute at the Christie Hospital in Manchester, England, believe that consumption of omega-3 fatty acids could block the spread of prostate cancer.  It has been known for some time that both omega-3 and omega-6 oils have promoted good health. 

Since the body can not make these fats, it is important to eat foods rich in them.  These foods include fish and fish oil, canola and flaxseed oils, and most raw nuts.  Nutritionists say it is important to keep a balance of the two fats / oils.  Some nutritionists believe that adults do better with fish oil rather than plant oils, but there are some benefits to the plant oils (nuts) as well. 

Dr. Mick Brown said “Omega-6 fats, found in vegetable oils, nuts and seeds, increased the spread of tumor cells into bone marrow. This invasion was blocked by omega 3 fats -- the ones found in oily fish.”  Brown is the chief scientist in the research.  Omega-3 Fatty Acids Prevent Spread of Prostate Cancer - Fish Oil Better Than Vegetable Sources - Omega-6 Used as Energy By Cancer Cells and Tumors


Size Difference in Breasts May be Cancer Predictor - Breast Symmetry New Risk Factor for Breast Cancer

Size Difference in Breasts May be Cancer Predictor - Breast Symmetry New Risk Factor for Breast Cancer

Breast Symmetry

There are a few predictors that may increase the risk of breast cancer.  Now it appears that breast symmetry may have something to do with the disease.  In fact, according to a study published in Breast Cancer Research, “breast asymmetry could be a reliable independent predictor of breast cancer.”

Very few women have perfectly symmetrical breasts according to a report on ABC News.  The researchers believe that the difference in size could be very important.  The relative odds of developing breast cancer increased by 1.5 with each 100ml increase in breast asymmetry. 

Diane Scutt from the University of Liverpool, UK and colleagues looked at 252 mammograms of women who did not have breast cancer at the time of the mammography, but later developed the disease.  Size Difference in Breasts May be Cancer Predictor - Breast Symmetry New Risk Factor for Breast Cancer 


Genetic Testing For Breast and Ovarian Cancers not Sufficient Enough for Recommendations of Invasive Prophylactic Surgeries - Study Shows

Genetic Testing For Breast and Ovarian Cancers not Sufficient Enough for Recommendations of Invasive Prophylactic Surgeries - Study Shows

Genetic Cancer Risks

There are some genetic tests that can be performed to determine the risk of breast and ovarian cancer, but not all cancers are associated with identified gene mutations. According to research by Mary-Claire King, Ph.D., of the University of Washington, Seattle, lifetime risks of breast cancer are as high as 80 percent among U.S. women with mutations in BRCA1 and BRCA2 genes.

Among white women in the US, mutations in the BRCA1 and BRCA2 genes account of 5 percent to 10 percent of the breast cancer cases.  The risk for young women with these particular inherited gene mutations is increasing.   

There are other gene mutations to look out for.  Inherited mutations in other genes, including CHEK2, TP53 and PTEN, can also influence risk of cancer.  There are some advantages for getting tested early for these and other gene mutations.  Genetic Testing For Breast and Ovarian Cancers not Sufficient Enough for Recommendations of Invasive Prophylactic Surgeries - Study Shows


Prostate Cancer may stall Tumor growth with Raloxifene Drug Treatment

Prostate Cancer may stall Tumor growth with Raloxifene Drug Treatment

Cancer Cells Dividing

Researchers from Cedars-Sinai found that a drug called Raloxifene may help in the treatment of men with prostate cancer.  Raloxifene is a drug that is currently on the market used to treat osteoporosis.  The complete report will be in the April 2006 issue of the British Journal of Urology International.

"We undertook this study because we desperately need new therapies for patients with advanced prostate cancer," said David B. Agus, M.D. who is the research director of the Louis Warschaw Prostate Cancer Center at Cedars-Sinai and also is the principal investigator of this study.  Prostate Cancer may stall Tumor growth with Raloxifene Drug Treatment


Skin Cancer and Human Papillomavirus HPV Link - No Cure But Treatment For Symptoms Available

Skin Cancer and Human Papillomavirus HPV Link - No Cure But Treatment For Symptoms Available

HPV

Researchers believe that the human papillomavirus (HPV) may play a role in the development of a certain type of skin cancer.  When comparing people with HPV to those that did not have it, a new study concludes that squamous cell skin cancers were significantly more likely to occur in people with antibodies in their blood to the beta form of HPV.

Scientists have already known that HPV is a significant cause of cervical cancer.  Now it appears it may play a role in certain skin cancers as well.  According to National Institutes of Health (NIH) there are more that 100 types of HPVs, over 30 types can be passed from one person to another through sexual contact.

The skin cancer study involved 252 squamous cell patients and 525 basal cell cancer patients and 461 healthy controls. The researchers adjusted their data for sun exposure and other known skin cancer risk factors. Skin Cancer and Human Papillomavirus HPV Link - No Cure But Treatment For Symptoms Available


Cancer Treatment - Taking Pride in the Advances in Radiation Therapy

Cancer Treatment - Taking Pride in the Advances in Radiation Therapy

"The Best News About Radiation Therapy" Book

Why is radiation therapy so stigmatized?  After all, it is a very useful treatment and its benefits far outweigh its risks.  How can a modality that cures cancer and spares people from mutilating cancer surgery, such as the removal of the voice box, a mastectomy, and the amputation of limbs, be so fearsome?

Unfortunately, people are misinformed. Also, most people’s perceptions of radiation therapy are colored by unfortunate anecdotes, which people have not put into their proper perspective. After all, one hears about bad outcomes when people travel in motor vehicles.  Yet, people do not fear the potential dangers of driving or being a passenger they way dread the thought of radiation therapy.  Furthermore, society does not make the distinction between cleanly prescribed medical radiation and nuclear accidents like Chernobyl.  Cancer Treatment - Taking Pride in the Advances in Radiation Therapy

 


FACTT Blood Test May Detect Cancer AIDS and Alzheimer’s Disease Early – Breakthrough Technology 100,000 Times More Sensitive than Current Tests

FACTT Blood Test May Detect Cancer AIDS and Alzheimer’s Disease Early – Breakthrough Technology 100,000 Times More Sensitive than Current Tests

Mark Green PhD

A new breakthrough technology may allow for early detection of some cancers, Alzheimer ’s disease, HIV and other deadly conditions.  The sensitivity of the test is 100,000 times higher than that of some other blood tests.  Another test, ELISA (enzyme-linked immunoadsorbent assay), is used as a diagnostic test to determine exposure to infectious agents, such as HIV, by identifying antibodies present in a blood sample.

The New FACTT (Florescent Amplification Catalyzed by T7-polymerase) test is much more sensitive.  One of the researchers, Hongtao Zhang, PhD, said "The current ELISA tests can only detect proteins when they are in high abundance. But the problem is that many of the functional proteins – those that have a role in determining your health – exist in very low amounts until diseases are apparent and cannot be detected or measured at early stages of medical pathology. It was important to develop a technique that can detect these rare molecules to detect abnormalities at an early stage."  FACTT Blood Test May Detect Cancer AIDS and Alzheimer’s Disease Early – Breakthrough Technology 100,000 Times More Sensitive than Current Tests


Prostate Cancer – PSA lowered, Tumor Growth Stalled and Cancer Cell Death by eating Capsaicin found in Hot Peppers

Prostate Cancer – PSA lowered, Tumor Growth Stalled and Cancer Cell Death by eating Capsaicin found in Hot Peppers

Habanera Hot Peppers

A study found that the capsaicin that is found in hot peppers caused prostate cancer cells to kill themselves.  Researchers from the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center and UCLA published their results in today’s issue of Cancer Research.

The capsaicin is what makes our tongue burn when eating a jalapeños hot pepper.  The researchers found that when they introduced the capsaicin to human prostate cancer cells it caused the cells to undergo a programmed cell death called apoptosis.  Prostate Cancer – PSA lowered, Tumor Growth Stalled and Cancer Cell Death by eating Capsaicin found in Hot Peppers


Colorectal Cancer Main Page - Colon Cancer Symptoms and Treatments

Colorectal Cancer Main Page - Colon Cancer Symptoms and Treatments

Intestines

Colorectal cancer is the second leading cause of cancer death in the United States.  There are over 130,000 cases diagnosed each year and over 50,000 deaths from the disease.  It can be survivable, especially if caught early.  This is why screening for colon cancer is so important.

There are several types of colon cancer including lymphoma, carcinoid tumors, melanoma, and sarcomas.  Colon carcinoma is the most common type.  There are several risk factors for colon cancer including family history, diet, obesity, even smoking and alcohol consumption.  Patients with a history of breast cancer have a slightly higher risk of developing colon cancer, and so do African Americans.  Men are more likely to develop colon cancer than women.

Although it has not been proven that a high fiber diet can lower the risk of colon cancer, most experts believe that a diet high in fat and meat diet low in fiber will increase the risk.  Colorectal Cancer Main Page - Colon Cancer Symptoms and Treatments 


Colon Cancer can be prevented with Early Colonoscopy Screening

Colon Cancer can be prevented with Early Colonoscopy Screening

American College of Gastroenterology

Experts from the American College of Gastroenterology say that not enough people in the United States get screened for color cancer.

Katie Couric host on NBC’s Today show lost her husband, Jay, to colorectal cancer in 1998.  Researchers have noticed a slight increase for people getting screened with a colonoscopy since she has become an advocate for the disease.  Researchers from the University of Michigan have called it “The Couric Effect.”

Although Couric has helped gain awareness and increased the screening for colon cancer there is still a shortfall in the number of people that get a colonoscopy.  The Centers for Disease Control & Prevention in 2002 said that there were only 41 percent of men and women over the age of 50 who had colonoscopy screenings in the last five years.  Colon Cancer can be prevented with Early Colonoscopy Screening


Stress May Increase Risk of Cancer - Generalized Anxiety Disorder (GAD) or Depression Treatments May Improve Immune System Response

Stress May Increase Risk of Cancer - Generalized Anxiety Disorder (GAD) or Depression Treatments May Improve Immune System Response

Stress May Affect Health

There may be a connection between stress and cancer. Sure cancer can cause stress, but new findings may help us determine if stress can cause cancer.  Previous research from the National Institute on Aging suggests that there may be link between chronic depression and cancer among older patients. 

Researchers found that when present for at least six years, depression was associated with an increased risk of cancer.  The study in 1998 found that the cancer rate among those depressed was 88 percent higher than other patients, according to report from CNN.

Now ABC News reports that Dr. Charles Raison said, ”Inflammatory pathways activated by stress have been implicated in the development of tumors, metastasis of tumors, and resistance to chemotherapy.”  Raison is professor of psychiatry and behavioral sciences and director of the Behavioral Immunology Clinic at Emory University in Atlanta.  Stress May Increase Risk of Cancer - Generalized Anxiety Disorder (GAD) or Depression Treatments May Improve Immune System Response


Christopher Reeve’s widow, Dana Reeve, Dies at age 44 of Lung Cancer

Christopher Reeve’s widow, Dana Reeve, Dies at age 44 of Lung Cancer

The Brook Ellison Story

Dana Reeve died on Monday at the Memorial Sloan-Kettering Medical Center of lung cancer at age 44.  She was married to Christopher Reeve who was well known as playing Superman in the 1980’s movies.  Christopher Reeve was paralyzed in a horse back riding accident in 1996 and had died on October 10th, 2004.

Dana Reeve along with Christopher Reeve spent much of there time to help find possible cures for paralysis and founded the Christopher Reeve Foundation.  Dana was a chairwoman of the Christopher Reeve Foundation.  Christopher Reeve’s widow, Dana Reeve, Dies at age 44 of Lung Cancer


UCLA Study Associates Estrogen with Breast Cancer - Hormone Replacement Therapy (HRT) Risk Increased Across Races

UCLA Study Associates Estrogen with Breast Cancer - Hormone Replacement Therapy (HRT) Risk Increased Across Races

Breast Cancer Cell

A new study says that there is an increased risk of breast cancer across ethnic groups in postmenopausal women treated with estrogen or estrogen-progestin therapy.  An earlier study suggested that estrogen-progestin therapy increased the risk of breast cancer.  The new study indicates the increased risk covers other ethnic groups as well.

The data was extrapolated from the Multiethnic Cohort Study of more than 55,000 women used to investigate the relationship between menopausal hormone therapy use and breast cancer risk.  This research shows a significant 29 percent increased risk of breast cancer over a 5 year period with current use of estrogen-progestin.  Previously it was believed the increased risk was only 10 percent.

Although the researchers found the increased risk of breast cancer among all ethnic groups with estrogen-progestin use, they did not find an increased risk among African American women using estrogen only.  UCLA Study Associates Estrogen with Breast Cancer - Hormone Replacement Therapy (HRT) Risk Increased Across Races


Breast Cancer – Possible increased risk by using Antiperspirant Deodorant

Breast Cancer – Possible increased risk by using Antiperspirant Deodorant

Aluminum free deodorant

Deodorants that contain aluminum salts may increase a woman’s risk of getting breast cancer.  Dr. Philippa Darbre from the University of Reading believes that more research should be conducted to further determine that it actually causes cancer.

The reason why scientists believe that the aluminum salts found in deodorants is harmful is because of the ability to mimic the oestrogen hormone in the body. If the deodorant can break through the skin it could become possible for the aluminum salts to enter the body.  A recent article published in the Journal of Applied Toxicology believes that research would be important to determine if the deodorant indeed increases the risk of breast cancer.  Breast Cancer – Possible increased risk by using Antiperspirant Deodorant


Cancer Risk increases with Obesity – More Young Children and Adults Overweight

Cancer Risk increases with Obesity – More Young Children and Adults Overweight

Obese Rat and Normal Rat

"Obesity increases the risk of contracting cancer," said Dr. Javier Salvador, Director of the Department of Endocrinology and Nutrition at the University Hospital of the University of Navarra.

Dr. Javier said that more people are overweight than ever before.  It is found in both industrialized countries and in developing countries as well.  He points out that in Spain 15% of the population suffers from obesity and 54% are overweight.  He believes that the cause for obesity is by people eating more calories and having a sedentary lifestyle.

Dr. Javier’s concerns for Western society is a rise in infant obesity. When these obese babies grow up they will become obese adults.  There are more obese children that are developing type II diabetes at young ages.  Cancer Risk increases with Obesity – More Young Children and Adults Overweight


Early Treatment of Prostrate Cancer had better Survival Rate

Early Treatment of Prostrate Cancer had better Survival Rate

PSA blood Test

This study shows that early treatment of prostrate cancer with radiation therapy or surgery may prolong survival rates compared to patients that are just observed to see if it gets worse before treating.  The study looked at the data of 48,000 men between the ages of 65 and 80 that had survived for at least one year after being diagnosed with localized prostate cancer from 1991 through 1999.  Yu-Ning Wong, M.D., an oncologist from the Fox Chase Cancer Center, presented the results of this study at the 2006 Prostate Cancer Symposium February 25th, in San Francisco.

Early diagnosis of prostate cancer can be diagnosed with a PSA (prostate-specific-antigen) blood test.  This blood test can detect very early stages of prostate cancer that are usually watched and not necessarily treated.  It is possible that the early prostate cancer may not be life threatening and may grow slowly.  Early Treatment of Prostrate Cancer had better Survival Rate


Embryonic Stem Cell Treatments Show Promise for Degenerative Diseases and Paralysis - Alzheimer's Parkinson's Cancer Heart Disease and More

Embryonic Stem Cell Treatments Show Promise for Degenerative Diseases and Paralysis - Alzheimer's Parkinson's Cancer Heart Disease and More

Embryonic Stem Cells

Stem cell research and treatment may yield extraordinary results for ailments including heart disease, Parkinson’s disease, cancer and diabetes.  Embryonic stem cells also show promise for people that are paralyzed. 

The CBS News program 60 minutes ran a segment on the subject Sunday night.  Ed Bradley’s report included an interview with Dr. Hans Keirstead, a 38-year-old biologist, who said he is ready to try a stem cell procedure on people paralyzed by spinal cord injuries.  The doctor’s earlier trial showed success in treating a laboratory rat whose hind legs were completely paralyzed. 

Amazingly, after injecting the rat with human embryonic stem cells, the paralyzed rat was able to move its hind legs.  Dr. Keirstead told Mr. Bradley that “If it does the same thing in humans, I think we’ve hit something here that’s gonna be truly remarkable."  He hopes to begin clinical trials on patients that have recently been paralyzed first.  Embryonic Stem Cell Treatments Show Promise for Degenerative Diseases and Paralysis - Alzheimer's Parkinson's Cancer Heart Disease and More


Treatment Options for Prostate Cancer – Radiation Surgery or Hormone Therapy

Treatment Options for Prostate Cancer – Radiation Surgery or Hormone Therapy

Prostate Diagram

There are 232,000 men diagnosed with prostate cancer in the US every year, and each man needs to make decision as to their treatment options.  There are some factors to consider before making a decision.

There are different types and prostate cancer.  According to Dr. Tim Johnson, a correspondent for ABC News Tonight, “In some cases — especially if a man has a slow-growing form of cancer or other more severe health conditions — "watchful waiting" may be all that is necessary. It involves regular exams and blood tests to make sure the cancer isn't spreading faster than predicted.”

In the Special Feature called “Second Option: Prostate Cancer,” Dr. Johnson interviewed Dr. Durado Brooks.  Brooks told the reporter that "The man should know, for instance, what is found at biopsy.  The biopsy gives information to the man and his treating physician in order to make a decision."  Brooks is Cancer Society director of prostate cancer.  Treatment Options for Prostate Cancer – Radiation Surgery or Hormone Therapy


Prostate Cancer May Be Linked to Virus - RNASEL Gene Defends against Viruses

Prostate Cancer May Be Linked to Virus - RNASEL Gene Defends against Viruses

Comon Flu Viruses

Researchers at the Cleveland Clinic and the University of California San Francisco have identified a new virus in human prostate tumors.  They are not sure whether this virus is linked to prostate cancer yet. 

The virus was found more often in human prostate tumors with two copies of the RNASEL gene mutation than in tumors with at least one normal copy of the gene, Forbes reported.  Dr. Eric Klein said "This is a virus that has never been seen in humans before. This is consistent with previous epidemiologic and genetic research that has suggested that prostate cancer may result from chronic inflammation, perhaps as a response to infection."  Dr. Klein is head of urologic oncology at the Cleveland Clinic's Glickman Urologic Institute.  Prostate Cancer May Be Linked to Virus - RNASEL Gene Defends against Viruses


Robotic Surgery in Treatment for Prostate Cancer - Antioxidants May not Prevent Prostate Cancer

Robotic Surgery in Treatment for Prostate Cancer - Antioxidants May not Prevent Prostate Cancer

Robotic Experiments

More than 230,000 men are diagnosed with prostate cancer every year.  A new study found that intake of dietary or supplemental antioxidants were not associated with a decreased risk of prostate cancer among men in the Prostate, Lung, Colorectal, and Ovarian (PLCO). 

The researchers found that vitamin E and beta-carotene supplementation may be associated with reduced prostate cancer risk in certain population subgroups.  Beta-carotene is a precursor to vitamin A. 

Vitamin E, C and carotenoids may play a role in preventing cancer development because of their ability to combat free radicals.  Free radicals are compounds that can cause damage to cellular DNA, lipid membranes, and proteins.  Robotic Surgery in Treatment for Prostate Cancer - Antioxidants May not Prevent Prostate Cancer


Lung Cancer – Tumor size determines likelihood of Cancer Spreading

Lung Cancer – Tumor size determines likelihood of Cancer Spreading

CT scanning equipment

In the February 13th issue of the Archives of Internal medicine a study reported that the smaller the tumors in lung cancer the less likely the cancer will spread.  The researchers believe that the earlier the detection, the better chance for successfully treating lung cancer.

The lead researcher, Claudia I. Henschke, M.D., Ph.D., New York Presbyterian Hospital–Weill Cornell Medical Center, New York, along with colleagues from the International Early Lung Cancer Action Program screened 28,689 men and women for lung cancer.  This took place at over 38 different medical institutions worldwide from 1993 through 2004.  The screenings were performed with a computed tomography (CT) scan.  Lung Cancer – Tumor size determines likelihood of Cancer Spreading


Botox could be used to help Shrink Cancer Tumors

Botox could be used to help Shrink Cancer Tumors

Botox

Botox may be used as part of the treatment of Cancer in the near future.  A research study from the Université de Louvain in Brussels, Belgium, led by Bernard Gallez, Ph.D., have been one of the first to explore how Botox could be used to treat cancer patients. 

First reported in the February 15th issue of Clinical Cancer Research, the results were hopeful.  When the Botox (Botulinum neurotoxin type A) was injected into two different kinds of tumors in mice, it caused the tumors’ cellular vasculature to open.  This improved circulation of the tumor made it more effective at killing off the cancer cells when using traditional chemotherapy and radiation treatments.

These are preliminary studies in mice and more research will need to be conducted.  The researchers hope that it will be used together with chemotherapy to make the treatment more effective and killing of the cancer.  Botox could be used to help Shrink Cancer Tumors


Study Conflicts – Does Hormone Replacement Therapy HRT Cause Heart Attacks Strokes or Breast Cancer?

Study Conflicts – Does Hormone Replacement Therapy HRT Cause Heart Attacks Strokes or Breast Cancer?

Dr. Lila Nachtigall

A study in 2002 showed an increase risk of breast cancer, stroke and heart attack for women that took hormone replacement therapy (HRT).  The researchers looked at the data from the Women’s Health Initiative (WHI), which began in the early 90’s with nearly 50,000 women.  Their findings left women with a tough decision:  Should they continue with the risky HRT or should they stop?

They found that women had a 30% increased risk of heart attack when taking HRT.  Now a follow up study has reevaluated the data, and found no increased risk of heart attack when women take estrogen alone, without progestin.

The research, published in the February 13th issue of archives of Internal Medicine – one of JAMA/Archives journals, said “Estrogen therapy does not appear to reduce the risk of heart attack or coronary death in healthy postmenopausal women, although some data suggest a lower coronary heart disease risk in women aged 50 to 59 years”.  Study Conflicts – Does Hormone Replacement Therapy HRT Cause Heart Attacks Strokes or Breast Cancer?


Does a Low Fat Diet Reduce the Risk of Breast Cancer? - Stroke? Heart Disease?

Does a Low Fat Diet Reduce the Risk of Breast Cancer? - Stroke? Heart Disease?

Fruit and Vegetable Diet

The new study by the Fred Hutchinson Cancer Research Center in Seattle, and colleagues with the Women's Health Initiative (WHI) Dietary Modification Trial that claims a low fat diet was no healthier than normal fat diet did more than raise eyebrows.  It has experts debating back and forth whether the study was legitimate.

Was it a flawed study?  The data was extrapolated from a huge number of participants; nearly 50,000 postmenopausal women.   Of those, 40% were asked to make dietary modifications including “consumption of a reduced amount of fat (20 percent of energy) and of an increased amount of vegetables and fruits (5 or more servings a day) and grains (6 or more servings a day).” The other 60% made no dietary modifications.

The study found little difference in breast cancer rates, cardiovascular disease or stroke.  The rate of breast cancer for the women that modified their diet was 3.35% while the rate for women that did not modify their diet was 3.66%.  The difference was considered slight.  Does a Low Fat Diet Reduce the Risk of Breast Cancer? - Stroke? Heart Disease?


Eating Vegetables may help boost DNA Repair and Guard against Cancer

Eating Vegetables may help boost DNA Repair and Guard against Cancer

Broccoli, Cabbage, and Cauliflower

Eating your vegetables is still good for you and the low-fat diet study shouldn’t get you to start a regular fast food diet of hamburgers.  The low-fat diet study currently in the news showed that a low-fat diet did not offer the cancer prevention health benefit menopausal women that lowered fat intake and increase fruits and vegetables.  Although the magnitude of the low-fat diet didn’t pan out, this study into vegetables reinforce the health benefits in cancer prevention.  This study was first published in Nature’s British Journal of Cancer and reflects how the chemical compounds found in certain vegetables can be beneficial in the prevention of cancer.  Eating Vegetables may help boost DNA Repair and Guard against Cancer


Low-Fat Diets are not as Beneficial as Thought

Low-Fat Diets not as Beneficial as Thought

Fruits and Vegetables

Postmenopausal women need to do more than just cut fat from their diet to stay healthy, according to a new study.  Researchers from the Fred Hutchinson Cancer Research Center in Seattle, and colleagues with the Women's Health Initiative (WHI) Dietary Modification Trial conducted a very large scale study. 

They followed 48,835 women for eight years and found that “a diet low in fat, but high in fruit, vegetables and grains, does not significantly reduce the risk of breast cancer in postmenopausal women.”  They examined the effect of a low-fat diet with the incidence of breast cancer. It was thought that a low fat diet would reduce breast cancer risk.  Low-Fat Diets are not as Beneficial as Thought


Smoking Pot Could Raise Risk of Bladder Cancer at a Younger Age

Smoking Pot Could Raise Risk of Bladder Cancer at a Younger Age

Dr. Martha Terris

New research shows that smoking marijuana may raise the risk for bladder cancer occurring at an early age.  Bladder cancer is more common among “people age 60 and older”, says Dr. Martha Terris, urologist at the Medical College of Georgia (MCG) and Veterans Affairs Medical Center in Augusta. 

Smoking cigarettes is a major risk factor for cancer, but smoking marijuana may be as bad as or worse than cigarette smoking as a risk factor for bladder cancer, according to the report.  Since it was known that cigarettes increased the risk, the researchers decided to investigate the risk for marijuana.

The VA hospitals affiliated with Stanford University Medical Center and MCG decided to investigate risk factors associated with exposure to tobacco, radiation, Agent Orange, smoked or processed meats and synthetic dyes used in the textile industry.  Smoking Pot Could Raise Risk of Bladder Cancer at a Younger Age


Breakthrough Treatments for Fighting Breast Cancer – Herceptin, Avastin, Femara and Lapatinib

Breakthrough Treatments for Fighting Breast Cancer – Herceptin, Avastin, Femara and Lapatinib

Avastin kills Cancer Cells

There are some exciting breakthroughs in the treatment of breast cancer.  Recently the FDA approved Femara for the treatment of early stage breast cancer.  It had already been used to treat the cancer in late stages of the disease.  Back in October an article in the New England Journal of Medicine described the drug Herceptin, and its effectiveness in treating a very aggressive form of the disease.

About 20 to 25 percent of the breast cancer cases are of the HER-2 variety and aggressively strike younger women.  The researchers found that the compound was able to reduce the reoccurrence of breast cancer in 46% of the women.

Recently ABC News had a segment on the new advances in fighting breast cancer.  The show mentioned Herceptin but also informed their viewers of a new drug that hopefully will be available soon called Lapatinib.  This experimental treatment may be better than Herceptin because it blocks two proteins in certain cancer cells, while Herceptin affects only one.  Breakthrough Treatments for Fighting Breast Cancer – Herceptin, Avastin, Femara and Lapatinib


Hormone Replacement Therapy (HRT) Benefits and Risks - Heart Disease vs Cancer and Stroke

Hormone Replacement Therapy (HRT) Benefits and Risks - Heart Disease vs Cancer and Stroke

Brigham Hospital

Women that start hormone replacement therapy (HRT) at a younger age are better off than women who start 10 years after menopause begins or after the age of 60, according to a new study.  Dr. JoAnn E. Manson of the Brigham and Women’s Hospital in Boston said “The timing of hormone therapy in relation to age and time since menopause may be a key factor in whether these hormones protect the heart or increase risk of heart disease.”

Manson and her colleagues were interested in the association between heart disease and HRT, as they relate to age.  They utilized women in the Nurses’ Health Study that was conducted between 1976 and 2000 to correlate a relationship.  From this data the team found that women who started HRT near the beginning of menopause had a significantly reduced risk of heart disease compared with women who didn't start HRT.  Hormone Replacement Therapy (HRT) Benefits and Risks - Heart Disease vs Cancer and Stroke


Study Says Omega-3 Fatty Acids Does Not Prevent Cancer - Fish Contains Omega3

Study Says Omega-3 Fatty Acids Does Not Prevent Cancer - Fish Contains Omega3

Omega 3 source

It appears that eating fish and taking supplements containing omega-3 fatty acids does not reduce cancer risk.  Catherine H. MacLean, M.D., Ph D, of RAND Health in Santa Monica California, and her colleagues looked at 38 articles published between 1966 and October 2005, and abstracted detailed data about the incidence of cancer. 

They compared cancer incidence with consumption of omega-3 and the elapsed time between the intervention and the “outcome measurements”.  Some of the epidemiological studies found that people that consume diets high in omega-3 fatty acids have a lower rate of some types of cancer.  The omega-3 acids are found in fish and some vegetables. 

Some of the smaller trials have attempted to connect omega-3 consumption with a lower incidence of cancer.  A number of dietary supplements containing omega-3 have labels that suggest that omega-3 fatty acids “protect against cancer”, even though the studies have reported mixed results. Study Says Omega-3 Fatty Acids Does Not Prevent Cancer - Fish Contains Omega3


Skin Cancer Melanoma have increased in California Hispanics

Skin Cancer Melanoma have increased in California Hispanics

Hat protects from Sun

A new study in the upcoming issue of CANCER medical journal reports of the increased rate of the deadly melanoma skin cancer among California Hispanics.

Hispanics have increased cases of melanoma compared to Caucasians and they tend to have confined thicker lesions which are more deadly.  Melanoma is not the most common type of skin cancer, but it is the most deadly.  Skin cancer is usually more dangerous when more layers of skin is penetrated with the tumor.  Melanoma cancer typically was at the highest risk for fair-skinned people.  Skin Cancer Melanoma have increased in California Hispanics


Cancer and Lymphoma Warnings on two Eczema Drugs

Cancer and Lymphoma Warnings on two Eczema Drugs

Elidel Cream

The FDA found two common eczema drugs, Elidel Cream (pimecrolimus) and Protopic Ointment (tacrolimus), have a possible risk for skin cancer and lymphoma. New warning labels are being added to the boxes of these medications to warn patients.

There has not been a concrete direct link for causing cancer; however there have been 78 cancer reports to the FDA with patients that have used these drugs.  The FDA’s Pediatric Drugs Advisory Committee wanted this warning put on packaging a year ago.  This was followed a month later with the FDA issuing a Public Health Advisory letting physicians now of the possible risk.  Cancer and Lymphoma Warnings on two Eczema Drugs

 


Bladder Cancer detection with a new easy in-office Urine Test

Bladder Cancer detection with a new easy in-office Urine Test

Matritech's NMP22 BladderChek

A report in today’s Journal of the American Medical Association told of an easy in-office urine test that can detect 99 percent of the tumors when used in conjunction with cystoscopy.

The $30 in-office urine test called the NMP22 BladderChek® manufactured by Matritech, who also funded the study at the University of Rochester Medical Center’s James P. Wilmot Cancer Center, looked at how accurate it was in the diagnosis of bladder cancer.  The urine test is non-invasive compared with the cystoscopy which is a flexible scope to see inside the urethra and bladder.  The cystoscopy by itself detects the bladder cancer 91 percent of the time, but when used with the urine test it is 99 percent accurate in diagnosis.  Bladder Cancer detection with a new easy in-office Urine Test

 

 


New Gene Discovery may lead to Treatment for GBM Brain Cancer

New Gene Discovery may lead to Treatment for GBM Brain Cancer

Dr. Habib

Research published today in the journal Cancer Research describes a gene EGFRvIII that generates a unique pattern of signaling.  This is a distinct gene that that causes a specific brain cancer to grow and multiply.

Glioblastoma multiforme (GBM) is a cancer of the supportive tissue of the brain and accounts for 60 percent of brain tumors in adults over the age of 50 years.  The team at UT Southwestern Medical Center discovered the cell-signaling mechanism instrumental in the most common brain cancer in adults.

Researchers already knew that tumor cells proliferate out of control by a mechanism characterized by an abnormally high number of copies of the epidermal growth factor receptor gene (EGFR). New Gene Discovery may lead to Treatment for GBM Brain Cancer


The Curry Spice Tumeric Curcumin and Cabbage Fight Prostate Cancer

The Curry Spice Tumeric Curcumin and Cabbage Fight Prostate Cancer

Curry Spice Tumeric Curcumin

Amazingly certain vegetables may hold “real potential for the treatment and prevention of prostate cancer”, according to research out of Rutgers' Ernest Mario School of Pharmacy.  The scientist discovered that the curry spice turmeric, also known as curcumin, when combined with watercress, cabbage, winter cress, broccoli, Brussels sprouts, kale, cauliflower, kohlrabi and turnips, significantly retarded the growth of cancerous tumors in mice.

There is a relatively high incidence of prostate cancer in the United States compared to India.  According to the researchers this has to do with dietary consumption of large amounts of plant-based foods rich in phytochemicals – nonnutritive plant chemicals that have protective or disease-preventive properties, by Indian men.  The Curry Spice Tumeric Curcumin and Cabbage Fight Prostate Cancer


Lung and Breast Cancer Detection may benefit by the Use of Dogs

Lung and Breast Cancer Detection may benefit by the Use of Dogs

Household dogs

Both breast and lung cancer are the leading causes of cancer death worldwide.  It may be possible to quickly screen people in early stages of the disease using dogs.  It appears dogs have an extraordinary scenting ability for both early and late stage cancers. 

According to a study led by Michael McCulloch of the Pine Street Foundation in San Anselmo California, and Tadeusz Jezierski of the Polish Academy of Sciences, Institute of Genetics and Animal Breeding, dogs can detect the cancers with accuracy (sensitivity and specificity) between 88 and 97 percent.

Scientists were first became aware to the idea of using canines for detection when a dog alerted its owner to the presence of a melanoma by constantly sniffing the skin lesion.  The canine olfactory discrimination can identify chemicals that are diluted as low as “parts per trillion”.  Lung and Breast Cancer Detection may benefit by the Use of Dogs


Breast Cancer Risk Reduced by Consuming Caffeinated Coffee

Breast Cancer Risk Reduced by Consuming Caffeinated Coffee

Benefits of Coffee

Caffeinated Coffee may reduce the risk of breast cancer in women, according to a new Canadian study.  The researchers examined women with a particular type of cancer associated with a specific gene mutation. The research is especially important for women with a family history of breast cancer.   

Looking at women with the BRCA1 and BRCA2 gene mutations the researchers found that women that drank more coffee had less of a risk of developing breast cancer.  According to the CTV Canadian website, Professor Steven A. Narod at the University of Toronto said “"Those women who drank six or more cups of coffee a day on average had about a 75 per cent reduction in the risk of breast cancer."  The women who drank 4 to 5 cups of coffee per day were able to reduce their risk 25% according to Reuters.  Reuters also claims the risk reduction for 6 or more cups per day was 69%.  Breast Cancer Risk Reduced by Consuming Caffeinated Coffee

Gene found to help Stop the Spread of Some Cancers

Gene found to help Stop the Spread of Some Cancers

Double Helix

In a recent article published in January 5th issue of Nature, a study showed that a gene is responsible for stopping the spread of some cancers.

The gene is called caspase 8 and it acts as a check point to make sure that skin cells stay with the skin, organ cells stay with the designated organ.  When a violation of a cell occurs it is the job of the caspase 8 to activate integrins which cause the cell to die off.

Childhood neuroblastoma cancer, show that there is a lack of the caspas 8 gene and is an aggressive cancer that occurs in children around the age of 2 years.  The gene is missing or suppressed in 70 percent of children with aggressive neuroblastomas.  The problem with this type of cancer is that it spreads throughout the body quickly and it hard to treat once it is diagnosed.  Gene found to help Stop the Spread of Some Cancers


FDA Approves Femara for Breast Cancer – Better than Tamoxifen

FDA Approves Femara for Breast Cancer – Better than Tamoxifen

Femara

Femara is now approved for treating early stage breast cancer in women past menopause.  Yesterday the FDA (Food and Drug Administration) granted Novartis, the manufacturer of Femara, this approval.  The drug has already been used to treat late stage breast cancer. 

Femara belongs to the class of drugs called aromatase inhibitors. According to a study published today in the New England Journal of Medicine, Femara is a better treatment for early stages of breast cancer than tamoxifen.  Femara does not have the side affects associated with Tamoxifen either.  These side effects have included endometrial cancer, and potentially fatal blood clots. FDA Approves Femara for Breast Cancer – Better than Tamoxifen


Increasing Vitamin D Intake may Prevent Common Cancers

Increasing Vitamin D Intake may Prevent Common Cancers

Vitamin D and Cancer

Vitamin D may play a bigger role in preventing colon cancer than fiber.  It appears to be the vitamin to take to fend off breast and ovarian cancers as well.  This is according to a study co-authored by Cedric F. Garland, a professor of medicine at the University of California, San Diego.

According to Garland, if you are black, older or live in the Northeast there is a good chance you don’t get enough vitamin D.  The vitamin has already been associated with bone health.

Researchers reviewed 63 studies relating vitamin D and cancer.  They found that people with low levels of vitamin D in the blood had higher rates of various common cancers.  Sometimes people that had low levels of vitamin D had a 50% increased risk of cancer.    Increasing Vitamin D Intake may Prevent Common Cancers


Breast Cancer Treatment with Tamoxifen not as effective for all Women

Breast Cancer Treatment with Tamoxifen not as effective for all Women

Tamoxifen

Tamoxifen can greatly reduce the risk of cancer relapse; however there may be some women who have a genetic variation that will make it less effective.  Researchers at the Mayo Clinic, Rochester, Minnesota found that a genetic variance changes the effectiveness of tamoxifen.

Matthew Goetz, MD, from the Department of Oncology,  reported in the December 20th issue of the  Journal of Clinical Oncology that one in 10 women in the U.S. have the variation of the level of cytochrome P4502D6 (or CYP2D6) which is a liver enzyme that is important for metabolizing tamoxifen.  Breast Cancer Treatment with Tamoxifen not as effective for all Women


New Cervical Cancer Vaccine More Effective in Younger Girls

New Cervical Cancer Vaccine More Effective in Younger Girls

Cancer Prevention

Clinical trials indicated that the new GlazoSmithKline uterine cancer vaccine Cervarix may be twice as effective for younger girls.  The results of the third phase of the trials compared the immune response of girls between the ages of 10 to 14 and girls between the ages of 15 and 24.

The clinical trials were conducted in Europe and Russia by the European drug maker Glaxo.  They involved 158 girls in the lower age group and 458 girls in the older age group.  Each girl received three doses of vaccine over a six month period.

The vaccine offered double the protective power for the younger group.  Forbes reported that Anna-Barbara Moscicki, a pediatrics professor from the University of California said “'Vaccination of pre-teen/adolescent girls against cancer-causing HPV (Human Papillomavirus) before onset of sexual activity will be an important part of the overall strategy for cervical cancer prevention.”  New Cervical Cancer Vaccine More Effective in Younger Girls


Cancer Vaccine Treatments Promising for Prostate and Brain Tumors

Cancer Vaccine Treatments Promising for Prostate and Brain Tumors

Cancer spread within 3 months

Research out of the UCLA’s Jonsson Cancer Center may provide for an effective treatment for a very fatal form of brain cancer.  Clinical trials volunteers are wanted for this treatment. 

Researchers believe that surgery combined with a vaccine may prove effective.  After removing the tumor surgically, a combination of the patients own tumor cells and white blood cells are used to create a vaccine.  Similar to other vaccines, this vaccine will prepare the body to fight off the cancer cells on their own.

A story recently appeared on NBC in Los Angeles concerning this research.  Dr. Linda Liau of UCLA told NBC that “The problem with brain cancer is that even with very little tumor cells left, the tumor comes back. It comes back in a matter of months”.  The type of cancer being investigated is almost 100 percent fatal.  Cancer Vaccine Treatments Promising for Prostate and Brain Tumors


Mayo Clinic Research determines A Cause for Cancer Cell Mutations

Mayo Clinic Research determines A Cause for Cancer Cell Mutations

Cell Structure

New research published in the December 15th issue journal Nature may explain why some cells are naturally “cancer proofed”.  A mechanism or state called aneuploidy (AN-u-ploy-dee) may have something to do with it.  Aneuploidy is a state where a cell has an abnormal number of chromosomes that creates cellular instability, giving rise to tumors.

The research was led by Dr. Jan van Deursen PhD at the Mayo Clinic.  Van Deursen told Best Syndication that "What we discovered is that there's an active process of cellular machinery that prevents aneuploidy.  It's a surveillance mechanism involving the two proteins Rae1-Nup98 that makes sure that in every cell division the proper number of chromosomes occur.”

There are two key proteins that work to cancer-proof a cell.  These proteins prevent premature segregation of duplicate chromosomes during cell (nuclear) division.  The new cancer players comprise a two-protein complex Rae1-Nup98.  Mayo Clinic Research determines A Cause for Cancer Cell Mutations


Drinking Black or Green Tea will Reduce the Risk of Ovarian Cancer

Drinking Black or Green Tea will Reduce the Risk of Ovarian Cancer

Tea

New research shows that drinking just two cups of tea a day can lower the risk of developing ovarian cancer by almost 50 percent.  Previous research has shown that drinking tea can lower the risk of developing some cancers, but this new study indicates it can lower the risk of ovarian cancer by half.

The Swedish Mammography Cohort looked at 61,057 women who were between 40 and 76 years old.  At the beginning of the study 68 percent of the women said they drank tea at least once a month.  Most drank black tea. 

After 15 years there were 301 women diagnosed with ovarian cancer.  Forbes reports that Dr. Susanna C. Larsson said that “We found a lower risk of ovarian cancer associated with greater tea consumption."  Amazingly each additional cup of tea reduced the risk of ovarian cancer by 18%.  Drinking Black or Green Tea will Reduce the Risk of Ovarian Cancer


Can Deodorants or Antiperspirants Cause Early Age Breast Cancer?

Do Deodorants or Antiperspirants Cause Breast Cancer

Aluminum Free Deodorant

Antiperspirants are drugs that contain aluminum and according to one researcher may be linked to breast cancer.  Dr. Kris McGrath of Northwestern University believes it is possible shaving and uses of antiperspirants habits may determine how quick women get breast cancer.

McGrath is not saying that all cases of breast cancer could be linked to antiperspirants and shaving.  Breast cancer existed long before we started making antiperspirants, but McGrath notes that when use of antiperspirant deodorants increased so did the incidence of breast cancer in an “almost parallel fashion”.

According to a recent CBS report rumors of a link between breast cancer and antiperspirants have been circulating for years, but have been written off as an urban legend by most people.  Even the Food and Drug Administration (FDA) calls it a “false… scary” story. Can Deodorants or Antiperspirants Cause Early Age Breast Cancer?


 

Study Finds Common Supplements and Diet can Help Prevent Disease

Study Finds Common Supplements and Diet can Help Prevent Disease

Folic Acid

The old saying “you are what you eat” may have more evidence to bolster its claims. Rats were injected with a specific amino acid which changed the way their genes were expressed.  It may be possible that dietary supplements or drugs could permanently halt the genetic effects that predispose people to mental and physical illnesses.

The research was conducted at the McGill University in Montreal Canada by Moshe Szyf, Michael Meaney and their colleagues.  They found that certain nutrients and supplements changed genetics by switching off certain genes in rodents, as reported in EureAlert.

Two years ago (New Scientist, 9 August 2003, p 14) a similar study was conducted where researchers found that the activity of a mouse's genes could be influenced by food supplements eaten by its mother just prior to or during the early stages of pregnancy. This research was conducted at Duke University. Study Finds Common Supplements and Diet can Help Prevent Disease


Drug Herceptin appears to Cure HER-2 Breast Cancer According to Journal

Drug Herceptin appears to Cure HER-2 Breast Cancer According to Journal

Cancer Cell

There appears to be a cure for women with HER II positive breast cancer, which accounts for 20 to 25 percent of breast cancer cases.  Women treated with Heceptin had a 46% reduction in reoccurring breast cancer. It is proving to be highly effective against an aggressive form of breast cancer that tends to strike younger women.

The New England Journal of Medicine reported that the drug Herceptin, which was licensed only for advanced breast cancer, has effectively targeted a specific protein that halted the spread of the disease.    

This my usher in a new era in cancer research where drugs are tailored made to target specific receptors identified for specific diseases.  The old method of research was based on trial and error where researchers screen thousand of compounds to find one that works.  Also, this particular drug targets only diseased cells.  Drug Herceptin appears to Cure HER-2 Breast Cancer According to Journal


Nanotechnology used to Kill Cancer Cells

July 28th 2005

Nanotechnology used to Kill Cancer Cells Nanocells

Non-invasive Methods to Treat Cancer Through Nanotechnology

Scientists at the Massachusetts Institute of Technology (MIT) in Boston have developed a method of delivering chemotherapy to the cancer cells, while leaving healthy cells undamaged.  They dub the device the “smart bomb”.  The research is published in this month’s journal Nature.

The scientists use nanotechnology to protect a medicinal supply of chemotherapy and angiogenesis agents until the nanocell enters the tumor.  The nonocell is described as a balloon inside a balloon with angiogenesis agents in the outer balloon and chemotherapy in the inner balloon.  The angiogenesis agents cause tumors to collapse. 

The nanocell’s surface is designed to avoid drawing the attention of the immune system.  The nanocells are small enough (only 200 nanometers) to pass through the tumor blood vessels. They are not small enough to pass through healthy tissue blood vessels.

This therapy has many benefits over standard chemo and radiation therapy.  Patients are less likely to suffer nausea, vomiting, hair loss and other side effects.  Also, when tested on mice, the mice using this therapy lived longer than their counterparts on traditional chemo and radiation therapies.  Nanotechnology used to Kill Cancer Cells


Allergy - Cancer DNA Link

Untreated Allergies may protect you

In the July 15th Issue of Cancer Research, Dr. Judith Schwartzbaum reported that people with asthma and allergies were at a lower risk of developing the most common type of malignant brain tumor. Dr. Schwartzbaum told Best Syndication " Drugs (allergy drugs) that block the products of these genes may block protection so maybe there are new cases of allergy (and not just better diagnosis) but treatment is blocking protection from this condition."

It is possible that the same genes that cause the allergic or asthma disorder may protect against the deadly glioblastoma multiforme (GBM) brain tumors. Dr. Schwartzbaum told Best Syndication in regards to the DNA findings "Your observation suggests it is the genetic variants themselves (no short term changes in these) rather than the diseases." She told us it may not be the Genes themselves, but the allergic reaction that protects the individual.  Allergy - Cancer DNA Link


SEPS1 Gene Discovered Regulates Inflammation in Humans

SEPS1 Gene Discovered Regulates Inflammation in Humans

Cell Inflammation

Researchers in the U.S. and Australia have discovered a gene that regulates inflammation.  They accessed the role of genetic variations in the selenoprotein S (SEPS1, also called SELS or SELENOS), a gene involved in stress response in the endoplasmic reticulum and inflammation control.

This could have far-reaching implications because inflammation has been shown to have an underlying role in cancer, cardiovascular disease, diabetes, obesity and Alzheimer’s diseases.  It has been reported that the research could lead to a therapy in two to four years.  RNA interference could play a role in therapy.  SEPS1 Gene Discovered Regulates Inflammation in Humans


New Compound may Stop the Spread of Lung Cancer

New Compound may Stop the Spread of Lung Cancer

Texas Researchers

Researchers at the University of Texas (UT) Southwest Medical Center have found a compound that shows promise in treating the spread of Lung Cancer.  The team used a compound called GRN163L blocks an enzyme that is known to keep cells immortal.  This enzyme has been implicated in almost all types of cancer.

"We showed for the first time that this drug can work in animals," said Dr. Jerry Shay, professor of cell biology at UT Southwestern and senior author of the study, which appears in the September issue of the journal Cancer Research.  They have determined that GRN163L works rapidly and in doses that would make for a reasonable therapy.

GRN163L specifically matches a stretch of DNA at the end of a chromosome segment called telomere.  Normally as cells divide and age telomeres become shorter and shorter.  After the telomeres reach a certain length the cell quits dividing. New Compound may Stop the Spread of Lung Cancer


Women with Benign Biopsies may still be at Risk for Cancer

Study shows women with benign biopsy may still have risk of breast cancer

Mammogram

Not all benign breast lumps are the same.  Most women that undergo a breast biopsy will be told their lump is benign.  Researcher in the New England Journal of Medicine compared different types of benign tissue in women.  Some benign biopsies resulted in higher risks than others.

The researchers identified 9087 women who received a benign breast disease diagnosis from the Mayo Clinic between the years 1967 and 1991.  Of the 9087 woman diagnosed with benign cells, 707 developed cancer within the next 15 years.   They compared the incidence of breast cancer with the expected incidence.  From this data the risks were estimated.  Complete Article


Curcumin may be used to treat Melanoma Cancer and what to look for Melanoma

Curcumin, a component in the yellow spice curry, may inhibit melanoma cell growth and kill tumor cells, according to a study published in the August 15th 2005 issue of Cancer, a peer-review journal of the American Cancer Society. In the new study, Dr Razelle Kurzrock at University of Texas Cancer Center in Houston, found that curcumin suppressed two specific proteins, NF-kappa B, and another independent inhibitor of apoptosis, IKK. These are two key stimulator compounds that inhibit cancer cell death.

Apoptosis is an intracellular mechanism for cells of all types to "kill" themselves. Curcumin, a spice found on turmeric, has been shown to inhibit tumor growth and stimulate apoptosis. Aggarwal’s team exposed three different cell lines of melanoma to curcumin, and found it decreased the cell viability in all three lines. They began to focus NF-kappa B, and found it shut down the tumor growth. 
Curcumin may be used to treat Melanoma Cancer and what to look for Melanoma


FDA advisory for Duragesic (fentanyl) Patch

The Food and Drug Administration (FDA) is investigating whether the Duragesic patch caused 120 deaths. Duragesic, a product of Johnson and Johnson, is a power trans-dermal (skin) pain patch that can relieve pain for up to 3 days.

It contains fentanyl, a potent narcotic as an active ingredient. It is possible that the 120 deaths were due to fentanyl overdose which is similar to a morphine overdose where the patients stops breathing or may fall into a coma.

Fentanyl is the same ingredient that was pumped into the Moscow theater during the 2002 hostage crisis. The intent was to put the hostages and Chechen hostage takers to sleep, but 120 of the 750 hostages died.

The FDA will look into whether the patches were defective or the directions were not followed. Some of the deaths may have been attributed to accidental misuse, where the crucial safety information on the drug's label was not followed.


Playing Video Games can Benefit Health

His research shows that computer games can act as a “cognitive distraction”, helping to relieve patients undergoing chemotherapy and treatment for sickle cell disease. The patients had less nausea and even lower systolic blood pressure. They also needed fewer analgesics.

Playing video games prevented a child from continually touching a cut. “The degree of attention needed to play such a game can distract the player from the sensation of pain”. “The child had neurodermatitis and scarring due to continual picking at his upper lip. Previous treatments had failed so the boy was given a hand held video game to keep his hands occupied.”

Griffiths has been observing children playing video games for 15 years. He warns some violent video games may make some people aggressive. It might be a good idea to mix game play with exercise to avoid obesity.

  
 
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Copyright 2005 Best Syndication                                            Last Updated Sunday, July 11, 2010 01:18 AM