Curcumin may be used to
treat Melanoma Cancer and what
to look for
July 11th 2005
Curcumin, a component in the yellow
spice curry, may inhibit melanoma cell growth and kill tumor cells,
according to a study published in the August 15th 2005 issue
of Cancer, a peer-review journal of the American Cancer Society. In the
new study, Dr Razelle Kurzrock at University of Texas
Cancer Center in Houston,
found that curcumin suppressed two specific
proteins, NF-kappa B, and
another independent inhibitor of apoptosis, IKK.
These are two key stimulator compounds that inhibit cancer cell death.
Apoptosis is an
intracellular mechanism for cells of all
types to "kill" themselves. Curcumin, a spice
found on turmeric, has been shown to inhibit tumor growth and stimulate
apoptosis. Aggarwal’s team exposed three different cell lines of
melanoma to curcumin, and found it decreased the cell viability in all
three lines. They began to focus NF-kappa B, and found it shut down the
Earlier studies found that curcumin has
antioxidant and anti-inflammation properties. The new report may
establish that curcumin may indeed cause tumor cell death in low doses
for a long period of time and high doses for shorter periods. Curcumin
did not suppress two pathways associated with melanoma cell
proliferation, B-Raf/MEK/ERK and Akt pathways. Further studies and human
trials are planned
Curcumin has been studied for 20 years as a preventative
measure against cancer. People with diets rich in curcumin have had
reduced rates of colon cancer. Now researchers are seriously
considering using it in combination with treatment.
Koumenis is now
studying whether curcumin can be used in conjunction with radiation
therapy for deadly brain tumors called gliomas.
begins in the melanocytes, a type of skin cell. Because most of these
cells keep on making melanin, melanoma tumors are often brown or black.
Melanoma most often appears on the trunk of fair-skinned men and on the
lower legs of fair-skinned women, but it can appear other places as
well. While having dark skin lowers the risk of melanoma, it does not
mean that a person with dark skin will never develop melanoma.
Skin cancers are
divided into nonmelanomas and melanomas. Melanoma is almost always
curable in its early stages. But it is also likely to spread to other
parts of the body. Melanoma is much less common than basal cell and
squamous cell skin cancers, but it is far more serious.
Best Syndication Staff Writer
Keywords and misspellings: non-melanomas
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